Down syndrome acute lymphoblastic leukemia, a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the International BFM Study Group

Libi Hertzberg, Elena Vendramini, Ithamar Ganmore, +21

Blood

Gain-of-function mutations in <i>interleukin-7 receptor-α</i> ( <i>IL7R</i> ) in childhood acute lymphoblastic leukemias

Chen Shochat, Noa Tal, Obul Reddy Bandapalli, +13

The Journal of Experimental Medicine

Mutations of JAK2 in acute lymphoblastic leukaemias associated with Down's syndrome

Dani Bercovich, Ithamar Ganmore, Linda M. Scott, +26

The Lancet

Down SyndromeHematological MalignancyAcute Lymphoblastic LeukaemiasMixed-phenotype Acute LeukemiaMalignant Blood Disorder +8

Induction of autophagy-dependent necroptosis is required for childhood acute lymphoblastic leukemia cells to overcome glucocorticoid resistance

Laura Bonapace, Beat Bornhäuser, Maike Schmitz, +7

Journal of Clinical Investigation

MitophagyMixed-phenotype Acute LeukemiaApoptosisImmunologyCell Death +22

Identification of ETV6-RUNX1-like and DUX4-rearranged subtypes in paediatric B-cell precursor acute lymphoblastic leukaemia

Henrik Lilljebjörn, Rasmus Henningsson, Axel Hyrenius‐Wittsten, +16

Nature Communications

<i>IKZF1</i>^plusDefines a New Minimal Residual Disease–Dependent Very-Poor Prognostic Profile in Pediatric B-Cell Precursor Acute Lymphoblastic Leukemia

Martin Stanulla, Elif Dağdan, Markéta Žaliová, +35

Journal of Clinical Oncology

Acute lymphoblastic leukemia in children with Down syndrome: a retrospective analysis from the Ponte di Legno study group

Trudy Buitenkamp, Shai Izraeli, Martin Zimmermann, +33

Blood

Ex vivo drug response profiling detects recurrent sensitivity patterns in drug-resistant acute lymphoblastic leukemia

Viktoras Frismantas, Maria Pamela Dobay, Anna Maria Rinaldi, +34

Blood

Genomics and drug profiling of fatal TCF3-HLF−positive acute lymphoblastic leukemia identifies recurrent mutation patterns and therapeutic options

Ute Fischer, Michael Förster, Anna Maria Rinaldi, +63

Nature Genetics

Therapeutic OptionsTumor BiologyHematological MalignancyMedicineImmunology +6

Presence of the P2RY8-CRLF2 rearrangement is associated with a poor prognosis in non–high-risk precursor B-cell acute lymphoblastic leukemia in children treated according to the ALL-BFM 2000 protocol

Gunnar Cario, Martin Zimmermann, Renja Romey, +11

Blood