Melanie Guérard

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( <i>SMN2</i> ) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA)

Hasane Ratni, Martin Ebeling, John D. Baird et al. · Journal of Medicinal Chemistry · 2018 · 492 citations · Full text

IWGT report on quantitative approaches to genotoxicity risk assessment I. Methods and metrics for defining exposure–response relationships and points of departure (PoDs)

James T. MacGregor, Roland Frötschl, Paul A. White et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2014 · 126 citations · Full text

IWGT report on quantitative approaches to genotoxicity risk assessment II. Use of point-of-departure (PoD) metrics in defining acceptable exposure limits and assessing human risk

James T. MacGregor, Roland Frötschl, Paul A. White et al. · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · 2014 · 123 citations · Full text

Extrapolation Methods, Genetic Epidemiology, Pathology +24

Interlaboratory evaluation of a multiplexed high information content in vitro genotoxicity assay

Steven M. Bryce, Derek T. Bernacki, Jeffrey C. Bemis et al. · Environmental and Molecular Mutagenesis · 2017 · 73 citations · Full text

An appraisal of critical effect sizes for the benchmark dose approach to assess dose–response relationships in genetic toxicology

Andreas Zeller, Gonzalo Durán-Pacheco, Melanie Guérard · Archives of Toxicology · 2017 · 53 citations

Benchmark Dose Approach, Medicine, Toxicology Testing +7