Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress

Anja Wilmes, Alice Limonciel, Lydia Aschauer, +23

Journal of Proteomics

Mechanism of cisplatin proximal tubule toxicity revealed by integrating transcriptomics, proteomics, metabolomics and biokinetics

Anja Wilmes, Chris Bielow, Christina Ranninger, +13

Toxicology in Vitro

ChromatinChromatin RemodelingMedicineNatural SciencesMolecular Biology +5

Delineation of the Key Aspects in the Regulation of Epithelial Monolayer Formation

Lydia Aschauer, Leonhard Gruber, Walter Pfaller, +11

Molecular and Cellular Biology

Cell AdhesionCytoskeletonMetabolic RemodelingKey AspectsEpithelial Maturation +22

Expression of xenobiotic transporters in the human renal proximal tubule cell line RPTEC/TERT1

Lydia Aschauer, Giada Carta, Nadine Vogelsang, +2

Toxicology in Vitro

Renal FunctionMolecular PhysiologyBiochemistryMedicineMembrane Transport +9

Lactate is an ideal non-invasive marker for evaluating temporal alterations in cell stress and toxicity in repeat dose testing regimes

Alice Limonciel, Lydia Aschauer, Anja Wilmes, +4

Toxicology in Vitro

Biomarker (Medicine)Preclinical Drug EvaluationCell StressStressMedicine +11

Application of RPTEC/TERT1 cells for investigation of repeat dose nephrotoxicity: A transcriptomic study

Lydia Aschauer, Alice Limonciel, Anja Wilmes, +7

Toxicology in Vitro

Reductive StressRenal FunctionTranscriptomic StudyMedicineImmunology +5

Transcriptomic alterations induced by Ochratoxin A in rat and human renal proximal tubular in vitro models and comparison to a rat in vivo model

Paul Jennings, Christina Weiland, Alice Limonciel, +11

Archives of Toxicology

Renal FunctionBiochemistryMedicinePharmacologyRenal Inflammation +8

Development of an in vitro renal epithelial disease state model for xenobiotic toxicity testing

Daniel Crean, Patricia Bellwon, Lydia Aschauer, +11

Toxicology in Vitro

UrologyRenal FunctionMedicineRenal PathologyPathology +9

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells

Alice Limonciel, Anja Wilmes, Lydia Aschauer, +9

Archives of Toxicology

Reductive StressRenal FunctionMolecular PhysiologyBiochemistryPhysiology +9

Evidence for a role of claudin 2 as a proximal tubular stress responsive paracellular water channel

Anja Wilmes, Lydia Aschauer, Alice Limonciel, +2

Toxicology and Applied Pharmacology

MechanobiologyMolecular PhysiologySignal TransductionOsmotic StressOsmoregulation +8