Combination IL-2 and IL-4 reduces glucocorticoid receptor-binding affinity and T cell response to glucocorticoids.

J C Kam, S.J. Szefler, Wendy Surs, +2

The Journal of Immunology

AsthmaInflammatory Lung DiseaseImmunologyImmune RegulationCd4 T Cell Responses +16

Association of Glucocorticoid Insensitivity with Increased Expression of Glucocorticoid Receptor β

Donald Y.M. Leung, Qutayba Hamid, Alessandra Vottero, +5

The Journal of Experimental Medicine

AsthmaInflammatory Lung DiseaseImmunologyGlucocorticoidIncreased Expression +16

Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy.

Ellen Sher, Donald Y.M. Leung, Wendy Surs, +4

Journal of Clinical Investigation

AsthmaInflammationSteroid-resistant AsthmaAllergyInflammatory Lung Disease +13

A novel action of IL-13: induction of diminished monocyte glucocorticoid receptor-binding affinity

Joseph D. Spahn, S.J. Szefler, Wendy Surs, +3

The Journal of Immunology

Allergen exposure decreases glucocorticoid receptor binding affinity and steroid responsiveness in atopic asthmatics.

Sai Nimmagadda, Stanley J. Szefler, Joseph D. Spahn, +2

American Journal of Respiratory and Critical Care Medicine

AsthmaInflammationGcr Binding AffinityEnvironmental AllergyAllergy +10

Steroid-resistant asthma: Immunologic and pharmacologic features

Jaime Alvarez, Wendy Surs, D LEUNG, +3

Journal of Allergy and Clinical Immunology

AsthmaSteroid-resistant AsthmaAllergyAllergy MedicineMedicine +4

Plasma histamine, epinephrine, cortisol, and leukocyte β-adrenergic receptors in nocturnal asthma

Stanley J. Szefler, R. Ando, Lisa Cicutto, +3

Clinical Pharmacology & Therapeutics

Reduced glucocorticoid binding affinity in asthma is related to ongoing allergic inflammation.

Joseph D. Spahn, Donald Y.M. Leung, Wendy Surs, +3

American Journal of Respiratory and Critical Care Medicine

AsthmaInflammationGcr AbnormalitiesAllergyInflammatory Lung Disease +11

Coexistence of glucocorticoid receptor and pharmacokinetic abnormalities: Factors that contribute to a poor response to treatment with glucocorticoids in children with asthma

Alan K. Kamada, Joseph D. Spahn, Wendy Surs, +3

The Journal of Pediatrics

AsthmaAllergyPharmacokinetic AbnormalitiesMedicinePediatrics +4

Cellular Mechanisms Contributing to Inadequate Response to Glucocorticoid Therapy

Ellen Sher, Donald Y.M. Leung, Wendy Surs, +4