Justin A. MacDonald

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

Brian D. Gulbransen, Mohammad Bashashati, Simon A. Hirota et al. · Nature Medicine · 2012 · 444 citations

Life Sciences, Neurobiology, Neuroscience +16

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Philip Kitchen, Mootaz M. Salman, Andrea Halsey et al. · Cell · 2020 · 441 citations · Full text

Medicine, Neuroscience, Pharmacology +17

NLRP3 inflammasome plays a key role in the regulation of intestinal homeostasis

Simon A. Hirota, Jeffrey Ng, Alan Lueng et al. · Inflammatory Bowel Diseases · 2010 · 430 citations · Full text

Life Sciences, Immunology, Pathology +17

Clostridium difficile Toxin–Induced Inflammation and Intestinal Injury Are Mediated by the Inflammasome

Jeffrey Ng, Simon A. Hirota, Yàn Li et al. · Gastroenterology · 2010 · 256 citations

Life Sciences, Immunology, Microbiology +12

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

Leanne Mortimer, France Moreau, Justin A. MacDonald et al. · Nature Immunology · 2016 · 250 citations

Life Sciences, Immunology, Pathology +14