The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

Verónica Torrano, Lorea Valcárcel-Jiménez, Ana R. Cortázar, +34

Nature Cell Biology

Metabolic Co-regulator Pgc1αMedicineCancer BiologyTumor SuppressorProstatic Disease +4

Diverse matrix metalloproteinase functions regulate cancer amoeboid migration

José L. Orgaz, Pahini Pandya, Rimple Dalmeida, +10

Nature Communications

Cancer Amoeboid MigrationMedicineCell-matrix InteractionCell MigrationMatrix Biology +5

Reactivation of p53 by a Cytoskeletal Sensor to Control the Balance Between DNA Damage and Tumor Dissemination

Cecilia Herráiz, Fernando Calvo, Pahini Pandya, +7

JNCI Journal of the National Cancer Institute

Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment

Mirella Georgouli, Cecilia Herráiz, Eva Crosas‐Molist, +18

Cell

Myosin II Reactivation and Cytoskeletal Remodeling as a Hallmark and a Vulnerability in Melanoma Therapy Resistance

José L. Orgaz, Eva Crosas‐Molist, Amine Sadok, +15

Cancer Cell

AMPK is a mechano-metabolic sensor linking cell adhesion and mitochondrial dynamics to Myosin-dependent cell migration

Eva Crosas‐Molist, Vittoria Graziani, Óscar Maiques, +15

Nature Communications

NMR Metabolomics of MTLn3E Breast Cancer Cells Identifies a Role for CXCR4 in Lipid and Choline Regulation

Louic S. Vermeer, Gilbert O. Fruhwirth, Pahini Pandya, +2

Journal of Proteome Research

Breast OncologyMetabolic RemodelingCxcr4 ExpressionCancer BiologyTumor Biology +17

A systematic pan-cancer study on deep learning-based prediction of multi-omic biomarkers from routine pathology images

Salim Arslan, Julian Schmidt, Cher Bass, +9

Communications Medicine

Matrix mechano-sensing at the invasive front induces a cytoskeletal and transcriptional memory supporting metastasis

Óscar Maiques, Marta C. Sallán, Roman Laddach, +31

Nature Communications

Deep learning can predict multi-omic biomarkers from routine pathology images: A systematic large-scale study

Salim Arslan, Debapriya Mehrotra, Julian Schmidt, +8

EngineeringMachine LearningDigital PathologyDiagnosisPathology +20