Wim Nerinckx

Necrostatin-1 analogues: critical issues on the specificity, activity and in vivo use in experimental disease models

Nozomi Takahashi, Linde Duprez, Sasker Grootjans et al. · Cell Death and Disease · 2012 · 438 citations · Full text

Critical Issues, Apoptosis, Immune Regulation +27

When PERK inhibitors turn out to be new potent RIPK1 inhibitors: critical issues on the specificity and use of GSK2606414 and GSK2656157

Diego Rojas‐Rivera, Tinneke Delvaeye, Ria Roelandt et al. · Cell Death and Differentiation · 2017 · 193 citations · Full text

Critical Issues, Medicine, Receptor Tyrosine Kinase +7

Crystallographic evidence for substrate ring distortion and protein conformational changes during catalysis in cellobiohydrolase Ce16A from Trichoderma reesei

Jinyu Zou, Gerard J. Kleywegt, Jerry Ståhlberg et al. · Structure · 1999 · 169 citations · Full text

Substrate Ring Distortion, Biochemistry, Natural Sciences +7

Disruption of endocytosis through chemical inhibition of clathrin heavy chain function

Wim Dejonghe, Isha Sharma, Bram Denoo et al. · Nature Chemical Biology · 2019 · 113 citations · Full text

Signal Transduction, Biochemistry, Medicine +11

A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes

Petra Tiels, E.V. Baranova, Kathleen Piens et al. · Nature Biotechnology · 2012 · 109 citations

Cellular Enzymology, Biochemistry, Natural Sciences +10