Ken Hirata

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

Anjan Debnath, Derek Parsonage, Rosa M. Andrade et al. · Nature Medicine · 2012 · 303 citations · Full text

Drug Target, Hit Identification, Health Sciences +11

A Clinical-Stage Cysteine Protease Inhibitor blocks SARS-CoV-2 Infection of Human and Monkey Cells

Drake M. Mellott, Chien‐Te K. Tseng, Aleksandra Drelich et al. · ACS Chemical Biology · 2021 · 116 citations

An unusual surface peroxiredoxin protects invasive Entamoeba histolytica from oxidant attack

Min‐Ho Choi, Dana Sajed, Leslie B. Poole et al. · Molecular and Biochemical Parasitology · 2005 · 86 citations

Microbial Toxin, Oxidant Attack, Invasive Entamoeba Histolytica +8

Cloning of a virulence factor of Entamoeba histolytica. Pathogenic strains possess a unique cysteine proteinase gene.

Sharon L. Reed, Jacques Bouvier, Andrew Pollack et al. · Journal of Clinical Investigation · 1993 · 81 citations · Full text

Microbial Toxin, Microbial Pathogens, Pathogenic Strains +15

Cysteine proteinases from distinct cellular compartments are recruited to phagocytic vesicles by Entamoeba histolytica

Xuchu Que, Linda S. Brinen, Penny Sue Perkins et al. · Molecular and Biochemical Parasitology · 2002 · 77 citations

Parasitic Protozoa, Pathogenesis, Immunology +7