Exosome-mediated delivery of Cas9 ribonucleoprotein complexes for tissue-specific gene therapy of liver diseases

Tao Wan, Jiafeng Zhong, Qi Pan, +3

Science Advances

In Vivo Gene TherapyImmunologyExtracellular MicrovesiclesGene DeliveryExosome Rnp +20

MOCAT: A Metagenomics Assembly and Gene Prediction Toolkit

Jens Roat Kultima, Shinichi Sunagawa, Junhua Li, +9

PLoS ONE

EngineeringGeneticsModular PipelineGenomicsBioinformatics Database +17

Microneedle-assisted genome editing: A transdermal strategy of targeting <i>NLRP3</i> by CRISPR-Cas9 for synergistic therapy of inflammatory skin disorders

Tao Wan, Qi Pan, Ping Yuan

Science Advances

Evidence that subcellular localization of a bacterial membrane protein is achieved by diffusion and capture

David Z. Rudner, Qi Pan, Richard Losick

Proceedings of the National Academy of Sciences

Protein SecretionSubcellular LocalizationMolecular BiologyCytoskeletonMembrane Transport +14

Rational Design of Poly(disulfide)s as a Universal Platform for Delivery of CRISPR-Cas9 Machineries toward Therapeutic Genome Editing

Jiajing Guo, Tao Wan, Bowen Li, +4

ACS Central Science

EngineeringMolecular BiologyTherapeutic Genome EditingGene DeliveryBiomedical Engineering +16

Self-Reinforcing Activation of a Cell-Specific Transcription Factor by Proteolysis of an Anti-σ Factor in B. subtilis

Qi Pan, Danielle A. Garsin, Richard Losick

Molecular Cell

Transcriptional RegulationSignal TransductionProtein ExpressionCell RegulationMolecular Regulation +11

Genome editing of mutant KRAS through supramolecular polymer-mediated delivery of Cas9 ribonucleoprotein for colorectal cancer therapy

Tao Wan, Yuxuan Chen, Qi Pan, +6

Journal of Controlled Release

Colorectal Cancer TherapyNovel TherapyNatural SciencesMutant KrasMolecular Biology +6

Trans-splicing in C. elegans generates the negative RNAi regulator ERI-6/7

Sylvia E. J. Fischer, Maurice D. Butler, Qi Pan, +1

Nature

Transcriptional RegulationNatural SciencesGeneticsRna SplicingRna Biology +8

Genome-editing prodrug: Targeted delivery and conditional stabilization of CRISPR-Cas9 for precision therapy of inflammatory disease

Xiaojie Yan, Qi Pan, Huhu Xin, +2

Science Advances

EngineeringIn Vivo Gene TherapyGenome-editing ProdrugImmunologyTherapeutics +17

A Duplex CRISPR-Cas9 Ribonucleoprotein Nanomedicine for Colorectal Cancer Gene Therapy

Tao Wan, Qi Pan, Chongyi Liu, +5

Nano Letters