Rogelio P. Frutos

Efficient Large-Scale Synthesis of BILN 2061, a Potent HCV Protease Inhibitor, by a Convergent Approach Based on Ring-Closing Metathesis

Nathan K. Yee, Vittorio Farina, Ioannis N. Houpis et al. · The Journal of Organic Chemistry · 2006 · 159 citations

Combinatorial Chemistry, Bioorganic Chemistry, Engineering +18

Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions

Steven R. Angle, Damian O. Arnaiz, J. P. BOYCE et al. · The Journal of Organic Chemistry · 1994 · 45 citations

Chemical Engineering, Molecular Sciences, Engineering +7

Development of a Safe and Economical Synthesis of Methyl 6-Chloro-5-(trifluoromethyl)nicotinate: Trifluoromethylation on Kilogram Scale

Jason A. Mulder, Rogelio P. Frutos, Nitinchandra D. Patel et al. · Organic Process Research & Development · 2013 · 31 citations

Chemical Engineering, Kilogram Scale, Engineering +11

An improved synthesis of N-aryl-hydantoin LFA-1 antagonists via the enantiospecific alkylation of an isobutyraldehyde-derived imidazolidinone template

Rogelio P. Frutos, Sandra Stehle, Laurence J. Nummy et al. · Tetrahedron Asymmetry · 2001 · 30 citations

Combinatorial Chemistry, Medicinal Chemistry, Enantioselective Synthesis +10

One-Pot Synthesis of 2,5-Disubstituted Pyrimidines from Nitriles

Rogelio P. Frutos, Xudong Wei, Nitinchandra D. Patel et al. · The Journal of Organic Chemistry · 2013 · 30 citations

Pyrimidine-containing Compounds, Combinatorial Chemistry, Bioorganic Chemistry +11