Ryan D. Guest

The clinical efficacy of first-generation carcinoembryonic antigen (CEACAM5)-specific CAR T cells is limited by poor persistence and transient pre-conditioning-dependent respiratory toxicity

Fiona Thistlethwaite, David E. Gilham, Ryan D. Guest et al. · Cancer Immunology Immunotherapy · 2017 · 409 citations · Full text

Life Sciences, Immunology, Oncology +17

The Role of Extracellular Spacer Regions in the Optimal Design of Chimeric Immune Receptors

Ryan D. Guest, Robert E. Hawkins, Eleanor J. Cheadle et al. · Journal of Immunotherapy · 2005 · 310 citations

Life Sciences, Immunology, Oncology +14

Primary Polyclonal Human T Lymphocytes Targeted to Carcino-Embryonic Antigens and Neural Cell Adhesion Molecule Tumor Antigens by CD3ζ-Based Chimeric Immune Receptors

David E. Gilham, Allison O'Neil, Chris Hughes et al. · Journal of Immunotherapy · 2002 · 67 citations

Life Sciences, Immunology, Oncology +17

Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial

Ryan D. Guest, Sam Mowbray, Hannah Gornall et al. · Cancer Immunology Immunotherapy · 2013 · 22 citations · Full text

Life Sciences, Biotechnology, Immunology +16

P53 integrity in the genetically engineered mammalian cell lines AHH-1 and MCL-5

Ryan D. Guest, James M. Parry · Mutation research. Fundamental and molecular mechanisms of mutagenesis · 1999 · 13 citations

Life Sciences, Genetics, Molecular Biology +14