Prostaglandin E2–EP4 signaling promotes immune inflammation through TH1 cell differentiation and TH17 cell expansion

Chengcan Yao, Daiji Sakata, Yoshiyasu Esaki, +5

Nature Medicine

InflammationCytokineImmune Cell DevelopmentTh17 Cell ExpansionImmunology +12

Prostaglandin E2–EP4 signaling initiates skin immune responses by promoting migration and maturation of Langerhans cells

Kenji Kabashima, Daiji Sakata, Miyako Nagamachi, +3

Nature Medicine

Immune RegulationImmunologyCell DeathInnate ImmunityDermatology +17

Thromboxane A2 modulates interaction of dendritic cells and T cells and regulates acquired immunity

Kenji Kabashima, Hiroyuki Tanaka, Toshiyuki Matsuoka, +9

Nature Immunology

InflammationAutoimmune DiseaseT-regulatory CellImmunologyImmunologic Mechanism +8

Prostaglandin F2α receptor signaling facilitates bleomycin-induced pulmonary fibrosis independently of transforming growth factor-β

Toru Oga, Toshiyuki Matsuoka, Chengcan Yao, +10

Nature Medicine

InflammationGrowth Factor-βFibrosisMolecular PhysiologyInflammatory Lung Disease +10

Prostaglandin E₂–prostoglandin E receptor subtype 4 (EP4) signaling mediates UV irradiation-induced systemic immunosuppression

Kitipong Soontrapa, Tetsuya Honda, Daiji Sakata, +8

Proceedings of the National Academy of Sciences

InflammationSignal TransductionMolecular PhysiologySignaling PathwayUv Irradiation +13

Impaired T lymphocyte trafficking in mice deficient in an actin-nucleating protein, mDia1

Daiji Sakata, Hiroyuki Taniguchi, Shingo Yasuda, +6

The Journal of Experimental Medicine

Dual roles of PGE ₂ -EP4 signaling in mouse experimental autoimmune encephalomyelitis

Yoshiyasu Esaki, Youxian Li, Daiji Sakata, +5

Proceedings of the National Academy of Sciences

Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1

Miyako Nagamachi, Daiji Sakata, Kenji Kabashima, +6

The Journal of Experimental Medicine

Prostaglandin I2–IP Signaling Promotes Th1 Differentiation in a Mouse Model of Contact Hypersensitivity

Saeko Nakajima, Tetsuya Honda, Daiji Sakata, +8

The Journal of Immunology

ImmunologyImmune RegulationImmunologic MechanismInnate ImmunityDermatology +22

DOCK8 Protein Regulates Macrophage Migration through Cdc42 Protein Activation and LRAP35a Protein Interaction

Akira Shiraishi, Takehito Uruno, Fumiyuki Sanematsu, +4

Journal of Biological Chemistry

Protein FunctionSignal TransductionSignaling PathwayCell SignalingImmunology +6