Pharmacological brake-release of mRNA translation enhances cognitive memory

Carmela Sidrauski, Diego Acosta‐Alvear, Arkady Khoutorsky, +15

eLife

Molecular RegulationConserved MechanismInitiation Factor 2Social SciencesSignaling Pathway +15

eIF2α Phosphorylation Bidirectionally Regulates the Switch from Short- to Long-Term Synaptic Plasticity and Memory

Mauro Costa‐Mattioli, Delphine Gobert, Elad Stern, +11

Cell

Synaptic PlasticityLong-term Synaptic PlasticityMolecular NeuroscienceSignal TransductionSynaptic Signaling +12

NMDA receptors are critical for unleashing consolidated auditory fear memories

Cyrinne Ben Mamou, Karine Gamache, Karim Nader

Nature Neuroscience

Auditory ProcessingNeurobiological MechanismNeuropsychologyCognitive SciencePsychiatry +10

PKMζ maintains memories by regulating GluR2-dependent AMPA receptor trafficking

Paola V. Migues, Oliver Hardt, Dong Wu, +4

Nature Neuroscience

Signal TransductionMolecular PhysiologyG Protein-coupled ReceptorReceptor (Biochemistry)Neuroscience +5

Metformin ameliorates core deficits in a mouse model of fragile X syndrome

Ilse Gantois, Arkady Khoutorsky, Jelena Popić, +18

Nature Medicine

Knockout MouseFragile X SyndromeFragile X SpectrumDegenerative DiseaseNeuroscience +5

Memory Retrieval Requires Ongoing Protein Synthesis and NMDA Receptor Activity-Mediated AMPA Receptor Trafficking

Joëlle Lopez, Karine Gamache, Rilla Schneider, +1

Journal of Neuroscience

Systemic mifepristone blocks reconsolidation of cue-conditioned fear; Propranolol prevents this effect.

Roger K. Pitman, Mohammed R. Milad, Sarah Igoe, +5

Behavioral Neuroscience

NeuropsychologyAffective NeurosciencePsychopharmacologyPharmacotherapySocial Sciences +19

Control of Synaptic Plasticity and Memory via Suppression of Poly(A)-Binding Protein

Arkady Khoutorsky, Akiko Yanagiya, Christos G. Gkogkas, +11

Neuron

Synaptic PlasticityMolecular NeuroscienceNeuromodulationMedicineSynaptic Transmission +8

Preclinical Evaluation of Reconsolidation Blockade by Clonidine as a Potential Novel Treatment for Posttraumatic Stress Disorder

Karine Gamache, Roger K. Pitman, Karim Nader

Neuropsychopharmacology

NeuropharmacologyPharmacotherapyPosttraumatic Stress DisorderReconsolidation BlockadeMedicine +4

Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2

Shane Wiebe, Anmol Nagpal, Vinh Tai Truong, +7

Proceedings of the National Academy of Sciences