Sean W. Fanning

ESR1 ligand-binding domain mutations in hormone-resistant breast cancer

Weiyi Toy, Yang Shen, Helen Won et al. · Nature Genetics · 2013 · 1.2K citations · Full text

Breast Oncology, Hormone-resistant Breast Cancer, Breast Cancer +5

Activating <i>ESR1</i> Mutations Differentially Affect the Efficacy of ER Antagonists

Weiyi Toy, Hazel M. Weir, Pedram Razavi et al. · Cancer Discovery · 2016 · 360 citations · Full text

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Sean W. Fanning, Christopher G. Mayne, Venkatasubramanian Dharmarajan et al. · eLife · 2016 · 297 citations · Full text

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

Sean W. Fanning, Rinath Jeselsohn, Venkatasubramanian Dharmarajan et al. · eLife · 2018 · 92 citations · Full text

Breast Oncology, Hormone Resistance, Pharmacotherapy +17

Stapled Peptides with γ‐Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction

Thomas E. Speltz, Sean W. Fanning, Christopher G. Mayne et al. · Angewandte Chemie International Edition · 2016 · 90 citations · Full text