Alastair C. Keen

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

J. Robert Lane, Ara M. Abramyan, Pramisha Adhikari et al. · eLife · 2020 · 40 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17

Optimization and 13CH3 methionine labeling of a signaling competent neurotensin receptor 1 variant for NMR studies

Fabian Bumbak, Alastair C. Keen, Natalie Gunn et al. · Biochimica et Biophysica Acta (BBA) - Biomembranes · 2018 · 39 citations

Life Sciences, Neuroscience, Pharmacology +8

Inhibition of the Proliferation of Human Lung Fibroblasts by Prostacyclin Receptor Agonists is Linked to a Sustained cAMP Signal in the Nucleus

Maxine J. Roberts, Lauren T. May, Alastair C. Keen et al. · Frontiers in Pharmacology · 2021 · 37 citations · Full text

Life Sciences, Molecular Biology, Pharmacology +16

LYCHOS is a human hybrid of a plant-like PIN transporter and a GPCR

Charles Bayly-Jones, Christopher J. Lupton, Alastair C. Keen et al. · Nature · 2024 · 36 citations · Full text

Life Sciences, Botany, Cell Biology +16

Molecular Determinants of the Intrinsic Efficacy of the Antipsychotic Aripiprazole

Carmen Klein Herenbrink, Ravi Kumar Verma, Herman D. Lim et al. · ACS Chemical Biology · 2019 · 25 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +16