Development of a controlled release formulation by continuous twin screw granulation: Influence of process and formulation parameters

Valérie Vanhoorne, Brecht Vanbillemont, Jurgen Vercruysse, +5

International Journal of Pharmaceutics

Formulation ParametersEngineeringMechanicsControlled Release FormulationMechanical Engineering +5

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses

Laurens Leys, Brecht Vanbillemont, Pieter-Jan Van Bockstal, +5

European Journal of Pharmaceutics and Biopharmaceutics

DesiccationContinuous Spin-freeze-dryingFood PreservationUnit DosesFood Engineering +2

New advances in the characterization of lyophilised orally disintegrating tablets

Brecht Vanbillemont, Hannelien Everaert, Thomas De Beer

International Journal of Pharmaceutics

New AdvancesExcipientsMedicinePharmaceutical TechnologyMicrobiology +1

Potential of Near-Infrared Chemical Imaging as Process Analytical Technology Tool for Continuous Freeze-Drying

Davinia Brouckaert, Laurens De Meyer, Brecht Vanbillemont, +7

Analytical Chemistry

EngineeringMicroscopyChemistryFood ChemistryDesiccation +22

Model-Based Optimisation and Control Strategy for the Primary Drying Phase of a Lyophilisation Process

Brecht Vanbillemont, Niels Nicolaï, Laurens Leys, +1

Pharmaceutics

EngineeringEngineering ThermodynamicsRefrigerationDesiccationSystems Engineering +19

The Impact of Formulation Composition and Process Settings of Traditional Batch Versus Continuous Freeze-Drying On Protein Aggregation

Brecht Vanbillemont, John F. Carpenter, Christine Probst, +1

Journal of Pharmaceutical Sciences

EngineeringFormulation CompositionFood QualityProtein AggregationProtein Folding +8

4D Micro-Computed X-ray Tomography as a Tool to Determine Critical Process and Product Information of Spin Freeze-Dried Unit Doses

Brecht Vanbillemont, Joris Lammens, Wannes Goethals, +3

Pharmaceutics

Computed TomographyEngineeringDifferential Scanning CalorimetryMicroscopyThermal Processing +24

Application of polyvinyl acetate in an innovative formulation strategy for lyophilized orally disintegrating tablets

Brecht Vanbillemont, Thomas De Beer

International Journal of Pharmaceutics

Pharmaceutical ScienceExcipientsMedicinePolymer SciencePolyvinyl Acetate +5

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying

Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, +7

Pharmaceutics

Freeze-thaw CyclingEngineeringDesiccationContinuous Freeze-dryingSpin Freezing Step +13

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses

Laurens De Meyer, Joris Lammens, Séverine Mortier, +6

International Journal of Pharmaceutics

EngineeringDesiccationUnit DosesThermal ModelingThermodynamics +4