A phase I study of the natural killer T-cell ligand alpha-galactosylceramide (KRN7000) in patients with solid tumors.

Giuseppe Giaccone, Cornelis J. A. Punt, Rita Ruijter, +10

PubMed

Sustained expansion of NKT cells and antigen-specific T cells after injection of α-galactosyl-ceramide loaded mature dendritic cells in cancer patients

D. Chang, Keren Osman, John E. Connolly, +14

The Journal of Experimental Medicine

Circulating Vα24+ Vβ11+ NKT Cell Numbers Are Decreased in a Wide Variety of Diseases That Are Characterized by Autoreactive Tissue Damage

Hans van Vliet, B. Mary E. von Blomberg, Nobusuke Nishi, +10

Clinical Immunology

InflammationWide VarietyAutoimmune DiseaseImmunologyImmune Regulation +10

Selective Decrease in Circulating Vα24+Vβ11+ NKT Cells During HIV Type 1 Infection

Hans van Vliet, B. Mary E. von Blomberg, Mette D. Hazenberg, +10

The Journal of Immunology

T-regulatory CellImmunologyImmune RegulationPathologyCd4 T Cell Responses +18

In vivo self-renewal of c-Kit+ Sca-1+ Lin(low/-) hemopoietic stem cells

Masatake Osawa, Kiwamu Nakamura, Nobusuke Nishi, +4

The Journal of Immunology

Human natural killer T cells acquire a memory-activated phenotype before birth

Hans van Vliet, Nobusuke Nishi, Tanja D. de Gruijl, +5

Blood

Potent expansion of human natural killer T cells using α-galactosylceramide (KRN7000)-loaded monocyte-derived dendritic cells, cultured in the presence of IL-7 and IL-15

Hans van Vliet, Nobusuke Nishi, Yasuhiko Koezuka, +6

Journal of Immunological Methods

InflammationImmunologyTumor ImmunityImmune RegulationPotent Expansion +10

α-Galactosylceramide in Chronic Hepatitis B Infection: Results from a Randomized Placebo-Controlled Phase I/ II Trial

Andrea M. Woltman, Martijn J. ter Borg, Rekha S. Binda, +8

Antiviral Therapy

Polarization of Valpha24+ Vbeta11+ natural killer T cells of healthy volunteers and cancer patients using alpha-galactosylceramide-loaded and environmentally instructed dendritic cells.

Hans van Vliet, Johan W. Molling, Nobusuke Nishi, +8

PubMed

T-regulatory CellImmunologyImmune RegulationImmunologic MechanismCancer Patients +14

Randomized placebo controlled phase I/II trial of α-galactosylceramide for the treatment of chronic hepatitis C

Bart J. Veldt, Hans van Vliet, B. Mary E. von Blomberg, +9

Journal of Hepatology

HepatologyHepatitis CViral HepatitisMedicineHepatitis +5