G Limjuco

A novel heterodimeric cysteine protease is required for interleukin-1βprocessing in monocytes

Nancy A. Thornberry, Herbert G. Bull, Jimmy Calaycay et al. · Nature · 1992 · 2.6K citations

Life Sciences, Immunology, Molecular Biology +12

Identification of a monocyte specific pre-interleukin 1 beta convertase activity.

Matthew J. Kostura, Michael J. Tocci, G Limjuco et al. · Proceedings of the National Academy of Sciences · 1989 · 512 citations · Full text

Life Sciences, Cell Biology, Immunology +14

IL-1-converting enzyme requires aspartic acid residues for processing of the IL-1 beta precursor at two distinct sites and does not cleave 31-kDa IL-1 alpha

Andrew Howard, Matthew J. Kostura, Nancy A. Thornberry et al. · The Journal of Immunology · 1991 · 323 citations

Life Sciences, Biochemistry, Molecular Biology +15

The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy.

Irwin Singer, S Scott, Jayne Chin et al. · The Journal of Experimental Medicine · 1995 · 155 citations · Full text

Life Sciences, Immunology, Molecular Biology +17

Interleukin 1 beta is localized in the cytoplasmic ground substance but is largely absent from the Golgi apparatus and plasma membranes of stimulated human monocytes.

Irwin Singer, S Scott, Gregory L. Hall et al. · The Journal of Experimental Medicine · 1988 · 148 citations · Full text

Life Sciences, Cell Biology, Immunology +11