Frank Sielaff

Cleavage of Influenza Virus Hemagglutinin by Airway Proteases TMPRSS2 and HAT Differs in Subcellular Localization and Susceptibility to Protease Inhibitors

Eva Böttcher‐Friebertshäuser, Catharina Freuer, Frank Sielaff et al. · Journal of Virology · 2010 · 215 citations · Full text

Life Sciences, Infectious Diseases, Molecular Biology +16

Identification of the first synthetic inhibitors of the type II transmembrane serine protease TMPRSS2 suitable for inhibition of influenza virus activation

Daniela Meyer, Frank Sielaff, Maya Hammami et al. · Biochemical Journal · 2013 · 139 citations

Life Sciences, Infectious Diseases, Medicinal Chemistry +14

Potent Inhibitors of Furin and Furin-like Proprotein Convertases Containing Decarboxylated P1 Arginine Mimetics

Gero L. Becker, Frank Sielaff, Manuel E. Than et al. · Journal of Medicinal Chemistry · 2009 · 118 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +13

Ligand Binding Stepwise Disrupts Water Network in Thrombin: Enthalpic and Entropic Changes Reveal Classical Hydrophobic Effect

Frank Sielaff, Felix Terwesten, A. Heine et al. · Journal of Medicinal Chemistry · 2012 · 89 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +16

Quantifying Protein-Ligand Binding Constants using Electrospray Ionization Mass Spectrometry: A Systematic Binding Affinity Study of a Series of Hydrophobically Modified Trypsin Inhibitors

Dragana Cubrilovic, Frank Sielaff, Torsten Steinmetzer et al. · Journal of the American Society for Mass Spectrometry · 2012 · 51 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +16