Joshua A. Sommers

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

Monika Aggarwal, Joshua A. Sommers, Robert H. Shoemaker et al. · Proceedings of the National Academy of Sciences · 2011 · 193 citations

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Niek van Wietmarschen, Sriram Sridharan, William J. Nathan et al. · Nature · 2020 · 182 citations · Full text

Tumor Heterogeneity, Genetics, Cancer Genomics +4

Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation

Parimal Karmakar, Jason Piotrowski, Robert M. Brosh et al. · Journal of Biological Chemistry · 2002 · 155 citations · Full text

Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1*[boxs]

Sudha Sharma, Joshua A. Sommers, Saba Choudhary et al. · Journal of Biological Chemistry · 2005 · 153 citations · Full text

DNA Sequences Proximal to Human Mitochondrial DNA Deletion Breakpoints Prevalent in Human Disease Form G-quadruplexes, a Class of DNA Structures Inefficiently Unwound by the Mitochondrial Replicative Twinkle Helicase

Sanjay Kumar Bharti, Joshua A. Sommers, Jun Zhou et al. · Journal of Biological Chemistry · 2014 · 135 citations · Full text

Chromatin, Genome Instability, Dna +11