Joshua A. Sommers

Werner syndrome protein interacts with human flap endonuclease 1 and stimulates its cleavage activity

Cayetano von Kobbe, Joshua A. Sommers, Parimal Karmakar et al. · The EMBO Journal · 2001 · 257 citations · Full text

Life Sciences, Genetics, Molecular Biology +8

Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress

Monika Aggarwal, Joshua A. Sommers, Robert H. Shoemaker et al. · Proceedings of the National Academy of Sciences · 2011 · 202 citations

Life Sciences, Cancer Biology, Molecular Biology +17

Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Niek van Wietmarschen, Sriram Sridharan, William J. Nathan et al. · Nature · 2020 · 199 citations · Full text

Life Sciences, Genetics, Molecular Genetics +10

Werner Protein Is a Target of DNA-dependent Protein Kinase in Vivo and in Vitro, and Its Catalytic Activities Are Regulated by Phosphorylation

Parimal Karmakar, Jason Piotrowski, Robert M. Brosh et al. · Journal of Biological Chemistry · 2002 · 155 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Biochemical Analysis of the DNA Unwinding and Strand Annealing Activities Catalyzed by Human RECQ1*[boxs]

Sudha Sharma, Joshua A. Sommers, Saba Choudhary et al. · Journal of Biological Chemistry · 2005 · 154 citations · Full text

Life Sciences, Genetics, Molecular Biology +15