An Isoleucine-based Allosteric Switch Controls Affinity and Shape Shifting in Integrin CD11b A-domain

Jian-Ping Xiong, Rui Li, Makram Essafi, +2

Journal of Biological Chemistry

EngineeringProtein AssemblyIntegrin Cd11b A-domainClosed ConformationMolecular Biology +14

Mycobacterium tuberculosis Virulent Factor ESAT-6 Drives Macrophage Differentiation Toward the Pro-inflammatory M1 Phenotype and Subsequently Switches It to the Anti-inflammatory M2 Phenotype

Amira Refai, Sami Gritli, Mohamed‐Ridha Barbouche, +1

Frontiers in Cellular and Infection Microbiology

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

Ichrak Riahi-Chebbi, Soumaya Souid, Houcemeddine Othman, +6

Scientific Reports

Chemoprevention StrategyTumor BiologyPolyphenolicsPhenolic Compound KaempferolDrug Resistance +14

Polycystin-1 Activates and Stabilizes the Polycystin-2 Channel

Gang Xu, Silvia González‐Perrett, Makram Essafi, +4

Journal of Biological Chemistry

Quince (Cydonia oblonga Miller) peel polyphenols modulate LPS-induced inflammation in human THP-1-derived macrophages through NF-κB, p38MAPK and Akt inhibition

Khadija Essafi‐Benkhadir, Amira Refai, Ichrak Riahi, +3

Biochemical and Biophysical Research Communications

InflammationMolecular PharmacologyMedicineImmune RegulationImmunology +9

Homeostatic chemokines increase survival of B-chronic lymphocytic leukemia cells through inactivation of transcription factor FOXO3a

Michel Ticchioni, Makram Essafi, P Jeandel, +4

Oncogene

Hematological MalignancyLymphoid NeoplasiaCell RegulationTranscription Factor Foxo3aMedicine +6

Voltage Dependence and pH Regulation of Human Polycystin-2-mediated Cation Channel Activity

Silvia González‐Perrett, Marisa Batelli, Kee‐Tae Kim, +6

Journal of Biological Chemistry

Lebein, a snake venom disintegrin, suppresses human colon cancer cells proliferation and tumor-induced angiogenesis through cell cycle arrest, apoptosis induction and inhibition of VEGF expression

Ons Zakraoui, Cezary Marcinkiewicz, Zohra Aloui, +9

Molecular Carcinogenesis

Heterodimeric DisintegrinChemoprevention StrategyApoptosisImmunologyCell Death +17

Quince peel polyphenolic extract blocks human colon adenocarcinoma LS174 cell growth and potentiates 5-fluorouracil efficacy

Ichrak Riahi-Chebbi, Meriam Haoues, Makram Essafi, +4

Cancer Cell International

FOXO3 Transcription Factor Regulates IL-10 Expression in Mycobacteria-Infected Macrophages, Tuning Their Polarization and the Subsequent Adaptive Immune Response

Rania Bouzeyen, Meriam Haoues, Mohamed‐Ridha Barbouche, +2

Frontiers in Immunology