The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι

Yiwen Zhang, Yingshi Chen, Yuzhuang Li, +21

Proceedings of the National Academy of Sciences

Viral PathogenesisImmunologyImmunologic MechanismViral Structural ProteinImmune System +16

Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses

Xiancai Ma, Fan Zou, Fei Yu, +22

Immunity

VaccinationReceptor Binding DomainCross-protectionVaccine DevelopmentImmunology +6

USP22 promotes hypoxia-induced hepatocellular carcinoma stemness by a HIF1α/USP22 positive feedback loop upon TP53 inactivation

Sunbin Ling, Qiaonan Shan, Qifan Zhan, +22

Gut

Mice Bearing HccCancer BiologyRedox BiologyTumor BiologyTranscriptional Regulation +22

Bispecific and split CAR T cells targeting CD13 and TIM3 eradicate acute myeloid leukemia

Xin He, Zijie Feng, Jian Ma, +9

Blood

INCB054828 (pemigatinib), a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3, displays activity against genetically defined tumor models

Phillip C.C. Liu, Holly K. Koblish, Liangxing Wu, +24

PLoS ONE

Fgfr AlterationsMedicinePharmacologySelective InhibitorPathology +12

An Lnc RNA (GAS5)/SnoRNA-derived piRNA induces activation of TRAIL gene by site-specifically recruiting MLL/COMPASS-like complexes

Xin He, Xinxin Chen, Xue Zhang, +14

Nucleic Acids Research

Systems BiologyDevelopmental BiologyEngineeringMedicineGenetics +13

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

Yu‐Lin Su, Xiuli Wang, Mati Mann, +14

Blood

Glycopeptide antibiotic teicoplanin inhibits cell entry of SARS-CoV-2 by suppressing the proteolytic activity of cathepsin L

Fei Yu, Ting Pan, Feng Huang, +23

Microbial PathogensViral DiagnosticsGlycobiologyViral PathogenesisImmunotherapeutics +17

Dual receptor T cells extend the immune repertoire for foreign antigens

Xin He, Charles A. Janeway, Matthew H. Levine, +4

Nature Immunology

Immune RepertoireForeign AntigensAutoimmune DiseaseT-regulatory CellImmunology +9

SIRT1 Activation Disrupts Maintenance of Myelodysplastic Syndrome Stem and Progenitor Cells by Restoring TET2 Function

Jie Sun, Xin He, Ying‐Hui Zhu, +30

Cell stem cell

Progenitor CellsLineage PlasticityCell RegulationMyelodysplastic Syndrome StemMedicine +10