Marcelo Actis

Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3

Hari Kamadurai, Yu Qiu, Alan Deng et al. · eLife · 2013 · 167 citations · Full text

NALP3 inflammasome upregulation and CASP1 cleavage of the glucocorticoid receptor cause glucocorticoid resistance in leukemia cells

Steven W. Paugh, Erik Bonten, Daniel Savic et al. · Nature Genetics · 2015 · 158 citations · Full text

Casp1 Cleavage, Signal Transduction, Nalp3 Inflammasome Upregulation +8

RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex

Nicholas G. Brown, Ryan T. VanderLinden, Edmond R. Watson et al. · Proceedings of the National Academy of Sciences · 2015 · 103 citations · Full text

A Small Molecule Inhibitor of Monoubiquitinated Proliferating Cell Nuclear Antigen (PCNA) Inhibits Repair of Interstrand DNA Cross-link, Enhances DNA Double Strand Break, and Sensitizes Cancer Cells to Cisplatin

Akira Inoue, Sotaro Kikuchi, Asami Hishiki et al. · Journal of Biological Chemistry · 2014 · 95 citations · Full text

Small molecule inhibitors of PCNA/PIP-box interaction suppress translesion DNA synthesis

Marcelo Actis, Akira Inoue, Benjamin J. Evison et al. · Bioorganic & Medicinal Chemistry · 2013 · 40 citations · Full text

Small Molecule Inhibitors, Biochemistry, Natural Sciences +7