Vikram Gurtu

Phosphodiesterase Type 5 Is Highly Expressed in the Hypertrophied Human Right Ventricle, and Acute Inhibition of Phosphodiesterase Type 5 Improves Contractility

Jayan Nagendran, Stephen L. Archer, Daniel Soliman et al. · Circulation · 2007 · 528 citations · Full text

Medicine, Cardiology, Pharmacology +17

Inhibition of pyruvate dehydrogenase kinase improves pulmonary arterial hypertension in genetically susceptible patients

Evangelos D. Michelakis, Vikram Gurtu, Linda Webster et al. · Science Translational Medicine · 2017 · 311 citations

Medicine, Cardiology, Pharmacology +7

Sirtuin 3 Deficiency Is Associated with Inhibited Mitochondrial Function and Pulmonary Arterial Hypertension in Rodents and Humans

Roxane Paulin, Peter Dromparis, Gopinath Sutendra et al. · Cell Metabolism · 2014 · 214 citations

Life Sciences, Biochemistry, Cell Biology +14

A miR-208–Mef2 Axis Drives the Decompensation of Right Ventricular Function in Pulmonary Hypertension

Roxane Paulin, Gopinath Sutendra, Vikram Gurtu et al. · Circulation Research · 2014 · 111 citations · Full text

Life Sciences, Cardiology, Molecular Biology +17

A dynamic and chamber-specific mitochondrial remodeling in right ventricular hypertrophy can be therapeutically targeted

Jayan Nagendran, Vikram Gurtu, David Z. Fu et al. · Journal of Thoracic and Cardiovascular Surgery · 2008 · 94 citations · Full text

Life Sciences, Cardiology, Cell Biology +13