Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

Martin Alberer, Ulrike Gnad-Vogt, Henoch S. Hong, +11

The Lancet

VaccinationVaccine SafetyVaccine DevelopmentMrna RabiesImmunology +4

Direct Injection of Protamine-protected mRNA: Results of a Phase 1/2 Vaccination Trial in Metastatic Melanoma Patients

Benjamin Weide, Steve Pascolo, Birgit Scheel, +7

Journal of Immunotherapy

Vaccination TrialImmunologyImmunologic MechanismImmunotherapeuticsDirect Injection +18

<i>In vivo</i> application of RNA leads to induction of specific cytotoxic T lymphocytes and antibodies

Ingmar Hoerr, Reinhard Obst, Hans‐Georg Rammensee, +1

European Journal of Immunology

Immune RegulationImmunologyImmunodominanceImmunologic MechanismAntigen Processing +18

Self-adjuvanted mRNA vaccination in advanced prostate cancer patients: a first-in-man phase I/IIa study

Hubert Kübler, Birgit Scheel, Ulrike Gnad-Vogt, +17

Journal for ImmunoTherapy of Cancer

Results of the First Phase I/II Clinical Vaccination Trial With Direct Injection of mRNA

Benjamin Weide, Jean‐Philippe Carralot, Anne Reese, +6

Journal of Immunotherapy

VaccinationTumor ImmunologyVaccine DevelopmentVaccine ResearchMedicine +13

Intradermal Vaccinations With RNA Coding for TAA Generate CD8+ and CD4+ Immune Responses and Induce Clinical Benefit in Vaccinated Patients

Susanne M. Rittig, Maik Haentschel, Katrin J Weimer, +12

Molecular Therapy

Spontaneous cellular uptake of exogenous messenger RNA in vivo is nucleic acid-specific, saturable and ion dependent

Jochen Probst, Benjamin Weide, Birgit Scheel, +4

Gene Therapy

Rna ProcessingNucleic Acid ChemistryNatural SciencesIon DependentRna Biology +9

Toll‐like receptor‐dependent activation of several human blood cell types by protamine‐condensed mRNA

Birgit Scheel, Regina Teufel, Jochen Probst, +9

European Journal of Immunology

A phase I/IIa study of the mRNA-based cancer immunotherapy CV9201 in patients with stage IIIB/IV non-small cell lung cancer

Martin Sebastian, Andreas Schröder, Birgit Scheel, +23

Cancer Immunology Immunotherapy

Cancer ImmunosurveillancePhase I/iia StudyMedicineImmunologyCancer Genomics +6

Polarization of immunity induced by direct injection of naked sequence-stabilized mRNA vaccines

Jean‐Philippe Carralot, Jochen Probst, Ingmar Hoerr, +5

Cellular and Molecular Life Sciences

VaccinationVaccine DevelopmentImmunologyTherapeutic VaccineAutoantigenomics +7