Colin Paul Spears

In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and -resistant murine colon adenocarcinomas.

Colin Paul Spears, Antranik Shahinian, Richard G. Moran et al. · PubMed · 1982 · 256 citations

Medicine, Oncology, Pharmacology +17

Mechanisms of innate resistance to thymidylate synthase inhibition after 5-fluorouracil.

Colin Paul Spears, Bengt Gustavsson, Magnus Berne et al. · PubMed · 1988 · 138 citations

Medicine, Oncology, Pharmacology +17

Thymidylate synthetase inhibition in malignant tumors and normal liver of patients given intravenous 5-fluorouracil.

Colin Paul Spears, Bengt Gustavsson, Malcolm S. Mitchell et al. · PubMed · 1984 · 131 citations

Medicine, Oncology, Pharmacology +16

Quantitation of intratumoral thymidylate synthase expression predicts for resistance to protracted infusion of 5-fluorouracil and weekly leucovorin in disseminated colorectal cancers: Preliminary report from an ongoing trial

Lawrence Leichman, Heinz‐Josef Lenz, Cynthia G. Leichman et al. · European Journal of Cancer · 1995 · 129 citations

Medicine, Oncology, Pharmacology +16

Biochemical determinants of tumor sensitivity to 5-fluorouracil: Ultrasensitive methods for the determination of 5-fluoro-2′-deoxyuridylate, 2′-deoxyuridylate, and thymidylate synthetase

Richard G. Moran, Colin Paul Spears, Charles Heidelberger · Proceedings of the National Academy of Sciences · 1979 · 121 citations · Full text

Life Sciences, Biochemistry, Pharmacology +17