Chikahisa Higuchi

IL-6 negatively regulates osteoblast differentiation through the SHP2/MEK2 and SHP2/Akt2 pathways in vitro

Shoichi Kaneshiro, Kosuke Ebina, Kenrin Shi et al. · Journal of Bone and Mineral Metabolism · 2013 · 220 citations · Full text

Medicine, Cell Biology, Oral Biology +10

Continuous Inhibition of MAPK Signaling Promotes the Early Osteoblastic Differentiation and Mineralization of the Extracellular Matrix

Chikahisa Higuchi, Akira Myoui, Nobuyuki Hashimoto et al. · Journal of Bone and Mineral Research · 2002 · 174 citations · Full text

Medicine, Medicinal Chemistry, Bone Metabolism +16

<i>In Vitro</i> Generation of a Scaffold-Free Tissue-Engineered Construct (TEC) Derived from Human Synovial Mesenchymal Stem Cells: Biological and Mechanical Properties and Further Chondrogenic Potential

Wataru Ando, Kosuke Tateishi, Daisuke Katakai et al. · Tissue Engineering Part A · 2008 · 134 citations

Engineering, Bioengineering, Biomedical Engineering +17

An Overgrowth Disorder Associated with Excessive Production of cGMP Due to a Gain-of-Function Mutation of the Natriuretic Peptide Receptor 2 Gene

Kohji Miura, Noriyuki Namba, Makoto Fujiwara et al. · PLoS ONE · 2012 · 122 citations · Full text

Life Sciences, Genetics, Molecular Genetics +16

Comparison of Human Serum with Fetal Bovine Serum for Expansion and Differentiation of Human Synovial MSC: Potential Feasibility for Clinical Applications

Kosuke Tateishi, Wataru Ando, Chikahisa Higuchi et al. · Cell Transplantation · 2008 · 108 citations · Full text

Engineering, Bioengineering, Biomedical Engineering +15