David S. Huang

Structural basis for species-selective targeting of Hsp90 in a pathogenic fungus

Luke Whitesell, Nicole Robbins, David S. Huang et al. · Nature Communications · 2019 · 121 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +17

Design and Synthesis of Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors

David S. Huang, Emmanuelle V. LeBlanc, Tanvi Shekhar‐Guturja et al. · Journal of Medicinal Chemistry · 2019 · 62 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity

Paul T. Marcyk, Emmanuelle V. LeBlanc, D.A. Kuntz et al. · Journal of Medicinal Chemistry · 2021 · 39 citations · Full text

Life Sciences, Biochemistry, Medicinal Chemistry +17

Discovery of FHD-286, a First-in-Class, Orally Bioavailable, Allosteric Dual Inhibitor of the Brahma Homologue (BRM) and Brahma-Related Gene 1 (BRG1) ATPase Activity for the Treatment of SWItch/Sucrose Non-Fermentable (SWI/SNF) Dependent Cancers

Rishi G. Vaswani, David S. Huang, Neville J. Anthony et al. · Journal of Medicinal Chemistry · 2025 · 24 citations

Medicine, Medicinal Chemistry, Pharmacology +11

Identification of the Metabolic Profile of the α-Tubulin-Binding Natural Product (−)–Pironetin

Sara K. Coulup, David S. Huang, H.L.S. Wong et al. · Journal of Medicinal Chemistry · 2019 · 15 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12