Stimulation of phospholipase C by guanine‐nucleotide‐binding protein βγ subunits

Montserrat Camps, Cuifen Hou, Dimitrios N. Sidiropoulos, +3

European Journal of Biochemistry

In Vivo Activity of a Phospholipase C Inhibitor, 1-(6-((17β-3-Methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1 H-pyrrole-2,5-dione (U73122), in Acute and Chronic Inflammatory Reactions

Cuifen Hou, Thomas Kirchner, Monica Singer, +3

Journal of Pharmacology and Experimental Therapeutics

Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites

Ping Du, John Salon, Joseph A. Tamm, +16

Protein Engineering Design and Selection

Signal TransductionBiochemistryFunctional SelectivityMedicineG Protein-coupled Receptor +12

Guanosine 5′-[<i>γ</i>-thio]triphosphate-stimulated hydrolysis of phosphatidylinositol 4,5-bisphosphate in HL-60 granulocytes. Evidence that the guanine nucleotide acts by relieving phospholipase C from an inhibitory constraint

Montserrat Camps, Cuifen Hou, K H Jakobs, +1

Biochemical Journal

Soluble Gtp-binding ProteinSoluble Phospholipase CHl-60 GranulocytesCellular PhysiologyGuanine Nucleotide Acts +20

Potent and selective CC-chemokine receptor-2 (CCR2) antagonists as a potential treatment for asthma

Bharat Lagu, Chrissy Gerchak, Meng Pan, +7

Bioorganic & Medicinal Chemistry Letters

InflammationAsthmaSelective Cc-chemokine Receptor-2MedicineImmunology +5

Synthesis, Structure−Activity Relationship and in Vivo Antiinflammatory Efficacy of Substituted Dipiperidines as CCR2 Antagonists

Mingde Xia, Cuifen Hou, Duane E. DeMong, +11

Journal of Medicinal Chemistry

Pharmaceutical SciencePharmacotherapyChemistryChemical BiologyPharmaceutical Chemistry +16

Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists

Jay M. Matthews, James J. McNally, Peter J. Connolly, +8

Bioorganic & Medicinal Chemistry Letters

Cannabis UsePsychoactive DrugTetrahydroindazole DerivativesSelective Cannabinoid-1Medicine +8

A novel series of N-(azetidin-3-yl)-2-(heteroarylamino)acetamide CCR2 antagonists

Nalin L. Subasinghe, James C. Lanter, Thomas Markotan, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesCcr2 Antagonists +6

Discovery of a 4-Azetidinyl-1-thiazoyl-cyclohexane CCR2 Antagonist as a Development Candidate

Xuqing Zhang, Cuifen Hou, Heather R. Hufnagel, +5

ACS Medicinal Chemistry Letters

Combinatorial Chemistry4-Azetidinyl-1-thiazoyl-cyclohexane Ccr2 AntagonistImmunologyCellular PharmacologyPharmacotherapy +16

Overcoming hERG activity in the discovery of a series of 4-azetidinyl-1-aryl-cyclohexanes as CCR2 antagonists

Xuqing Zhang, Heather R. Hufnagel, Thomas Markotan, +9

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryHeterocyclicBiochemistryFunctional SelectivityMedicine +9