Mali Cosden

Identification and in Vivo Evaluation of Liver X Receptor β-Selective Agonists for the Potential Treatment of Alzheimer’s Disease

Shawn J. Stachel, Celina Zerbinatti, Michael T. Rudd et al. · Journal of Medicinal Chemistry · 2016 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Decreased glucocerebrosidase activity and substrate accumulation of glycosphingolipids in a novel GBA1 D409V knock-in mouse model

Nicole K. Polinski, Terina N. Martinez, A. Gorodinsky et al. · PLoS ONE · 2021 · 41 citations · Full text

Life Sciences, Genetics, Neurology +17

Early intervention of tau pathology prevents behavioral changes in the rTg4510 mouse model of tauopathy

Xiaohai Wang, Karen D.B. Smith, Michelle Pearson et al. · PLoS ONE · 2018 · 38 citations · Full text

Life Sciences, Neurology, Neuroscience +17

O2‐13‐04: Early Clinical Results and Preclinical Validation of the O‐Glcnacase (OGA) Inhibitor Mk‐8719 as a Novel Therapeutic for the Treatment of Tauopathies

Sean M. Smith, Arie Struyk, Daniel Jonathan et al. · Alzheimer s & Dementia · 2016 · 23 citations

Medicine, Pharmacology, Pharmacotherapy +17

A novel glucosylceramide synthase inhibitor attenuates alpha synuclein pathology and lysosomal dysfunction in preclinical models of synucleinopathy

Mali Cosden, Sarah Jinn, Lihang Yao et al. · Neurobiology of Disease · 2021 · 20 citations · Full text

Life Sciences, Neurobiology, Neuroscience +17