TOP1 inhibition therapy protects against SARS-CoV-2-induced lethal inflammation

Jessica Ho, Bobo Wing-Yee Mok, Laura Campisi, +50

Cell

Top1 Inhibition TherapyImmunologyAntiviral ResponseAntiviral Drug Development

Antibiotics Disrupt Coordination between Transcriptional and Phenotypic Stress Responses in Pathogenic Bacteria

Paul A. Jensen, Zeyu Zhu, Tim van Opijnen

Cell Reports

Virus-assisted directed evolution of enhanced suppressor tRNAs in mammalian cells

Delilah Jewel, Rachel E. Kelemen, Rachel L. Huang, +9

Nature Methods

Viral ReplicationSynthetic VirologyNatural SciencesMolecular BiologyVirology +6

The Transcriptional landscape of Streptococcus pneumoniae TIGR4 reveals a complex operon architecture and abundant riboregulation critical for growth and virulence

Indu Warrier, Nikhil Ram-Mohan, Zeyu Zhu, +5

PLoS Pathogens

BacteriologyMolecular BiologyTranscriptomics TechnologyTranscriptional LandscapeTranscriptional Regulation +15

The Landscape of Phenotypic and Transcriptional Responses to Ciprofloxacin in Acinetobacter baumannii: Acquired Resistance Alleles Modulate Drug-Induced SOS Response and Prophage Replication

Edward Geisinger, Germán Vargas-Cuebas, Nadav J. Mortman, +9

mBio

Hybrid Gene Origination Creates Human-Virus Chimeric Proteins during Infection

Jessica Ho, Matthew Angel, Yixuan Ma, +51

Cell

Entropy of a bacterial stress response is a generalizable predictor for fitness and antibiotic sensitivity

Zeyu Zhu, Defne Surujon, Juan C. Ortiz‐Marquez, +4

Nature Communications

A Novel Tetramethylpyrazine Derivative Protects Against Glutamate-Induced Cytotoxicity Through PGC1α/Nrf2 and PI3K/Akt Signaling Pathways

Haiyun Chen, Jie Cao, Zeyu Zhu, +6

Frontiers in Neuroscience

Tetramethylpyrazine Nitrone Reduces Oxidative Stress to Alleviate Cerebral Vasospasm in Experimental Subarachnoid Hemorrhage Models

Liangmiao Wu, Zhiyang Su, Ling Zha, +7

NeuroMolecular Medicine

Cerebral Vascular RegulationNeurophysiologyMedicineReperfusion InjuryPharmacology +12

Enhanced Directed Evolution in Mammalian Cells Yields a Hyperefficient Pyrrolysyl tRNA for Noncanonical Amino Acid Mutagenesis

Delilah Jewel, Rachel E. Kelemen, Rachel L. Huang, +8

Angewandte Chemie International Edition