Daniel Simard

Dependence on the Pyrimidine Biosynthetic Enzyme DHODH Is a Synthetic Lethal Vulnerability in Mutant KRAS-Driven Cancers

Malvika Koundinya, Judith Sudhalter, Albane Courjaud et al. · Cell chemical biology · 2018 · 118 citations

Biosynthesis, Biochemistry, Natural Sciences +5

Discovery of MK-7246, a selective CRTH2 antagonist for the treatment of respiratory diseases

Michel Gallant, Christian Beaulieu, Carl Berthelette et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 49 citations · Full text

Respiratory Diseases, Pharmacology, Mechanism Of Action +5

Structurally simplified biphenyl combretastatin A4 derivatives retain in vitro anti-cancer activity dependent on mitotic arrest

Daniel Tarade, Dennis Ma, Christopher Pignanelli et al. · PLoS ONE · 2017 · 31 citations · Full text

Chemoprevention Strategy, Molecular Biology, Medicinal Chemistry +16

Comparison of adjuvants to optimize influenza neutralizing antibody responses

Rebecca S. Rudicell, Marie Garinot, Masaru Kanekiyo et al. · Vaccine · 2019 · 28 citations · Full text

Vaccination, Cross-protection, Immunology +7

Design, synthesis, and thrombin-inhibitory activity of pyridin-2-ones as P2/P3 core motifs

Stephen Hanessian, Daniel Simard, Malken Bayrakdarian et al. · Bioorganic & Medicinal Chemistry Letters · 2008 · 27 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Biochemistry +6