Ruilin Tian

Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway

Xiaoyan Guo, Giovanni Aviles, Yi Liu et al. · Nature · 2020 · 672 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +8

CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons

Ruilin Tian, Mariam A. Gachechiladze, Connor Ludwig et al. · Neuron · 2019 · 602 citations · Full text

Life Sciences, Cell Biology, Genetics +15

Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis

Ruilin Tian, Anthony Abarientos, Jason Hong et al. · Nature Neuroscience · 2021 · 415 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +15

Heterochromatin anomalies and double-stranded RNA accumulation underlie <i>C9orf72</i> poly(PR) toxicity

Yong‐Jie Zhang, Lin Guo, Patrick Gonzales et al. · Science · 2019 · 229 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation

John J. Chen, Diane Nathaniel, Preethi Raghavan et al. · Journal of Biological Chemistry · 2019 · 190 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +17