Heparin-binding EGF-like growth factor and ErbB signaling is essential for heart function

Ryo Iwamoto, Satoru Yamazaki, Masanori Asakura, +12

Proceedings of the National Academy of Sciences

Matrix Metalloproteinase-3 Releases Active Heparin-binding EGF-like Growth Factor by Cleavage at a Specific Juxtamembrane Site

Masashi Suzuki, Gerhard Raab, Marsha A. Moses, +2

Journal of Biological Chemistry

The membrane protein CD9/DRAP 27 potentiates the juxtacrine growth factor activity of the membrane-anchored heparin-binding EGF-like growth factor.

Shigeki Higashiyama, Ryo Iwamoto, K. Goishi, +4

The Journal of Cell Biology

Toxin ReceptorSignal TransductionMolecular PhysiologyTumor MicroenvironmentMitogenic Activity +12

Mouse preimplantation blastocysts adhere to cells expressing the transmembrane form of heparin-binding EGF-like growth factor

Gerhard Raab, Karen Kover, Bibhash C. Paria, +3

Development

Heparin-binding EGF-like growth factor

Gerhard Raab, Michael Klagsbrun

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

Growth HormoneFibroblast Growth FactorCell GrowthMedicineCell Biology +3

The Shedding of Membrane-anchored Heparin-binding Epidermal-like Growth Factor Is Regulated by the Raf/Mitogen-activated Protein Kinase Cascade and by Cell Adhesion and Spreading

Ze’ev Gechtman, José Luís Izquierdo Alonso, Gerhard Raab, +2

Journal of Biological Chemistry

Heparin-binding EGF-like growth factor is an autocrine growth factor for human urothelial cells and is synthesized by epithelial and smooth muscle cells in the human bladder.

Michael R. Freeman, James J. Yoo, Gerhard Raab, +6

Journal of Clinical Investigation

Human BladderHuman GrowthAutocrine Growth FactorCell GrowthCrm 197 +16

Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin-binding EGF-like growth factor independently of protein kinase C

Sandra M. Dethlefsen, Gerhard Raab, Marsha A. Moses, +3

Journal of Cellular Biochemistry

Bronchial epithelial compression regulates MAP kinase signaling and HB-EGF-like growth factor expression

Daniel J. Tschumperlin, Jonathan D. Shively, Melody A. Swartz, +4

American Journal of Physiology-Lung Cellular and Molecular Physiology

Biosynthesis and Processing by Phorbol Ester of the Cell Surface-Associated Precursor Form of Heparin-Binding EGF-like Growth Factor

Gerhard Raab, S. Higashiyama, S Hetelekidis, +4

Biochemical and Biophysical Research Communications

BiosynthesisEngineeringProtein ExpressionPhorbol EsterCell Proliferation +7