Combination therapy with anti-HIV-1 antibodies maintains viral suppression

Pilar Mendoza, Henning Gruell, Lilian Nogueira, +33

Nature

Human RetrovirusImmunologyAntiviral TherapyAntiviral ResponseVirology +4

Broadly Neutralizing Antibodies and Viral Inducers Decrease Rebound from HIV-1 Latent Reservoirs in Humanized Mice

Ariel Halper-Stromberg, Ching-Lan Lu, Florian Klein, +13

Cell

Humanized MiceViral PersistenceNeutralizing AntibodiesHuman RetrovirusHiv-1 Latent Reservoirs +7

Enhanced clearance of HIV-1–infected cells by broadly neutralizing antibodies against HIV-1 in vivo

Ching-Lan Lu, Dariusz K. Murakowski, Stylianos Bournazos, +11

Science

ImmunologyImmunodominanceAntiviral DrugImmunotherapyEnhanced Clearance +15

Combination anti-HIV-1 antibody therapy is associated with increased virus-specific T cell immunity

Julia Niessl, Amy E. Baxter, Pilar Mendoza, +11

Nature Medicine

Human RetrovirusImmunologyAntiviral TherapyAntiviral ResponseAutoimmunity +6

Non-neutralizing Antibodies Alter the Course of HIV-1 Infection In Vivo

Joshua A. Horwitz, Yotam Bar‐On, Ching-Lan Lu, +10

Cell

Primary ImmunodeficiencyHuman RetrovirusImmunologyAntiviral ResponseVirology +7

Combination of quadruplex qPCR and next-generation sequencing for qualitative and quantitative analysis of the HIV-1 latent reservoir

Christian Gaebler, Julio C. C. Lorenzi, Thiago Y. Oliveira, +8

The Journal of Experimental Medicine

Relationship between latent and rebound viruses in a clinical trial of anti–HIV-1 antibody 3BNC117

Yehuda Z. Cohen, Julio C. C. Lorenzi, Lisa Krassnig, +18

The Journal of Experimental Medicine

Relationship between intact HIV-1 proviruses in circulating CD4 ⁺ T cells and rebound viruses emerging during treatment interruption

Ching-Lan Lu, Joy A. Pai, Lilian Nogueira, +11

Proceedings of the National Academy of Sciences