Leanne M. Buzon

Utilizing Structures of CYP2D6 and BACE1 Complexes To Reduce Risk of Drug–Drug Interactions with a Novel Series of Centrally Efficacious BACE1 Inhibitors

Michael A. Brodney, Elizabeth M. Beck, Christopher R. Butler et al. · Journal of Medicinal Chemistry · 2015 · 78 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

A Second-Generation Oral SARS-CoV-2 Main Protease Inhibitor Clinical Candidate for the Treatment of COVID-19

Charlotte Allerton, Joel T. Arcari, Lisa Aschenbrenner et al. · Journal of Medicinal Chemistry · 2024 · 73 citations · Full text

Medicine, Infectious Diseases, Pharmacology +15

Discovery of small molecule isozyme non-specific inhibitors of mammalian acetyl-CoA carboxylase 1 and 2

Jeffrey W. Corbett, Kevin D. Freeman‐Cook, Richard L. Elliott et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 58 citations · Full text

Life Sciences, Biochemistry, Pharmacology +12

Maximizing Lipophilic Efficiency: The Use of Free-Wilson Analysis in the Design of Inhibitors of Acetyl-CoA Carboxylase

Kevin D. Freeman‐Cook, Paul A. Amor, Scott J. Bader et al. · Journal of Medicinal Chemistry · 2011 · 54 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of a Series of Efficient, Centrally Efficacious BACE1 Inhibitors through Structure-Based Drug Design

Christopher R. Butler, Michael A. Brodney, Elizabeth Beck et al. · Journal of Medicinal Chemistry · 2015 · 46 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17