Subcellular Discharge of a Serine Protease Mediates Release of Invasive Malaria Parasites from Host Erythrocytes

Sharon Yeoh, Rebecca A. O’Donnell, Konstantinos Koussis, +10

Cell

Protease InhibitorsBiochemistryParasitic ProtozoaPathogenesisMalaria +7

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

David A. Baker, Lindsay B. Stewart, Jonathan M. Large, +25

Nature Communications

High throughput screening for inhibitors of the HECT ubiquitin E3 ligase ITCH identifies antidepressant drugs as regulators of autophagy

Mario Rossi, Barak Rotblat, Keith H. Ansell, +8

Cell Death and Disease

Optimization of primers for cloning libraries of mouse immunoglobulin genes using the polymerase chain reaction

Catherine Kettleborough, José W. Saldanha, Keith H. Ansell, +1

European Journal of Immunology

Inhibition of Papillomavirus Protein Function in Cervical Cancer Cells by Intrabody Targeting

Heather Griffin, Robert C. Elston, Deborah Jackson, +4

Journal of Molecular Biology

Cervical Cancer ManagementCancer-associated VirusCervical CancerDrug TargetingHuman Papillomavirus Vaccines +10

Discovery of Plasmodium vivax<i>N</i>-Myristoyltransferase Inhibitors: Screening, Synthesis, and Structural Characterization of their Binding Mode

Victor Gonçalves, J.A. Brannigan, David Whalley, +6

Journal of Medicinal Chemistry

Structural CharacterizationDrug TargetBioorganic ChemistryMalariaMolecular Biology +15

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

Olivier A. Pierrat, Kvido Střı́šovský, Yonka Christova, +5

ACS Chemical Biology

Peptide EngineeringPeptide ScienceChemical BiologyPharmaceutical ChemistryMedicinal Chemistry +16

Imidazopyridazine Inhibitors of Plasmodium falciparum Calcium-Dependent Protein Kinase 1 Also Target Cyclic GMP-Dependent Protein Kinase and Heat Shock Protein 90 To Kill the Parasite at Different Stages of Intracellular Development

Judith L. Green, Robert W. Moon, David Whalley, +14

Antimicrobial Agents and Chemotherapy

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

Timothy M. Chapman, Simon A. Osborne, Nathalie Bouloc, +9

Bioorganic & Medicinal Chemistry Letters

Vitro AdmeAntiparasitic AgentMalariaImmunologySelective Inhibitors +14

Optimization of an Imidazopyridazine Series of Inhibitors of <i>Plasmodium falciparum</i> Calcium-Dependent Protein Kinase 1 (<i>Pf</i>CDPK1)

Timothy M. Chapman, Simon A. Osborne, Claire Wallace, +8

Journal of Medicinal Chemistry

Drug TargetAntiparasitic AgentMalariaPharmaceutical ChemistryDrug Resistance +15