Jonathan M. Large

A potent series targeting the malarial cGMP-dependent protein kinase clears infection and blocks transmission

David A. Baker, Lindsay B. Stewart, Jonathan M. Large et al. · Nature Communications · 2017 · 173 citations · Full text

Imidazo[4,5-<i>b</i>]pyridine Derivatives As Inhibitors of Aurora Kinases: Lead Optimization Studies toward the Identification of an Orally Bioavailable Preclinical Development Candidate

Vassilios Bavetsias, Jonathan M. Large, Chongbo Sun et al. · Journal of Medicinal Chemistry · 2010 · 81 citations · Full text

Monocyclic β-Lactams Are Selective, Mechanism-Based Inhibitors of Rhomboid Intramembrane Proteases

Olivier A. Pierrat, Kvido Střı́šovský, Yonka Christova et al. · ACS Chemical Biology · 2010 · 64 citations · Full text

Peptide Engineering, Peptide Science, Chemical Biology +18

Substituted imidazopyridazines are potent and selective inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1)

Timothy M. Chapman, Simon A. Osborne, Nathalie Bouloc et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 53 citations · Full text

Vitro Adme, Antiparasitic Agent, Malaria +16

Imidazopyridazines as potent inhibitors of Plasmodium falciparum calcium-dependent protein kinase 1 (PfCDPK1): Preparation and evaluation of pyrazole linked analogues

Jonathan M. Large, Simon A. Osborne, Ela Smiljanic-Hurley et al. · Bioorganic & Medicinal Chemistry Letters · 2013 · 40 citations · Full text