Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor

Naftaly Meydan, T Grunberger, Harjit Dadi, +9

Nature

Hematological MalignancyMalignant Blood DisorderImmunologyHematologyMedicine +2

The development of inflammatory TH-17 cells requires interferon-regulatory factor 4

Anne Brüstle, Sylvia Heink, Magdalena Huber, +7

Nature Immunology

InflammationCytokineAutoimmune DiseaseImmune Cell DevelopmentMedicine +9

Defective T cell receptor signaling and CD8+ thymic selection in humans lacking Zap-70 kinase

Enrico Arpaia, Michal Shahar, Harjit Dadi, +2

Cell

Cd8+ Thymic SelectionSignal TransductionAutoimmune DiseaseZap-70 KinaseLymphocyte Development +10

Abelson-interactor-1 promotes WAVE2 membrane translocation and Abelson-mediated tyrosine phosphorylation required for WAVE2 activation

Yan Leng, Jinyi Zhang, Karen Badour, +5

Proceedings of the National Academy of Sciences

Molecular RegulationMolecular BiologyCytoskeletonCellular PhysiologySignaling Pathway +17

Identification of an altered splice site in Ashkenazi Tay-Sachs disease

Enrico Arpaia, Anne Dumbrille-Ross, Thomas Maler, +12

Nature

GeneticsPathogenesisPathologyMolecular BiologyAltered Splice Site +3

Mitochondrial Basis for Immune Deficiency

Enrico Arpaia, Patricia Benveniste, Antonio Di Cristofano, +7

The Journal of Experimental Medicine

Pnp DeficiencyT-regulatory CellImmunologyImmune RegulationCell Death +14

The interaction between caveolin-1 and Rho-GTPases promotes metastasis by controlling the expression of alpha5-integrin and the activation of Src, Ras and Erk

Enrico Arpaia, Heiko Blaser, Miguel Quintela-Fandiño, +13

Oncogene

Flotillin-2 deficiency leads to reduced lung metastases in a mouse breast cancer model

Thorsten Berger, Tsutomu Ueda, Enrico Arpaia, +9

Oncogene

Lung MetastasesFlotillin-2 DeficiencyBreast OncologyMedicinePathology +7

HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1

Miguel Quintela-Fandiño, Enrico Arpaia, Dirk Brenner, +9

Proceedings of the National Academy of Sciences

Systems BiologyOncologySignal TransductionBasal Breast CancerSignaling Pathway +12

IMMUNODEFICIENCY CAUSED BY PURINE NUCLEOSIDE PHOSPHORYLASE DEFICIENCY

Amos Cohen, Eyal Grunebaum, Enrico Arpaia, +1

Immunology and Allergy Clinics of North America

Primary ImmunodeficiencyAutoimmune DiseasePathologyAutoimmunityMedicine +2