Interaction of endogenous opioid peptides and other drugs with four kappa opioid binding sites in guinea pig brain

Richard B. Rothman, Victor Bykov, Brian R. de Costa, +3

Peptides

Opioid EpidemicNeurophysiologyAddictionMedicineNeuropeptide Receptor +12

beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.

Richard B. Rothman, Joseph B. Long, Victor Bykov, +3

Journal of Pharmacology and Experimental Therapeutics

Chronic administration of morphine and naltrexone up-regulate μ-opioid binding sites labeled by [3H][D-Ala2, MePhe4, Gly-ol5]enkephalin: further evidence for two μ-binding sites

Richard B. Rothman, Victor Bykov, Joseph B. Long, +4

European Journal of Pharmacology

Opioid EpidemicMolecular PharmacologyBiochemistryMedicineChronic Administration +10

Upregulation of the opioid receptor complex by the chronic administration of morphine: A biochemical marker related to the development of tolerance and dependence

Richard B. Rothman, Joseph B. Long, Victor Bykov, +4

Peptides

Opioid EpidemicPain MedicineChronic AdministrationMolecular PainBiochemical Marker +14

Chronic administration of morphine and naltrexone up-regulate[3H][d-ala2,d-leu5]enkephalin binding sites by different mechanisms

Janine A. Danks, Frank C. Tortella, Joseph B. Long, +5

Neuropharmacology

Different MechanismsSignal TransductionFunctional SelectivityMedicineChronic Administration +7

Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: Evidence for a two-site allosteric model

Richard B. Rothman, Wayne D. Bowen, Victor Bykov, +5

Neuropeptides

Molecular PharmacologyTwo-site Allosteric ModelBiochemistryMedicineNeurotransmitter +9

Pharmacological activities of optically pure enantiomers of the κ opioid agonist, U50,488, and its cis diastereomer: evidence for three κ receptor subtypes

Richard B. Rothman, Charles P. France, Victor Bykov, +4

European Journal of Pharmacology

Molecular PharmacologyFunctional SelectivityMedicinePure EnantiomersPharmacological Activities +6

Interaction of opioid peptides and other drugs with multiple kappa receptors in rat and human brain. Evidence for species differences

Richard B. Rothman, Victor Bykov, Bowen Xue, +6

Peptides

Molecular PharmacologyHealth SciencesAddictionMedicineBehavioral Pharmacology +10

Selective and enantiospecific acylation of .kappa.-opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide. Demonstration of .kappa. receptor heterogeneity

Brian R. de Costa, Richard B. Rothman, Victor Bykov, +2

Journal of Medicinal Chemistry

Molecular PharmacologyBiochemistryMedicineAltmetric Attention ScoreMechanism Of Action +10

Preparation of rat brain membranes highly enriched with opiate kappa binding sites using site-directed acylating agents: Optimization of assay conditions

Richard B. Rothman, Victor Bykov, Janine A. Danks, +4

Neuropeptides

Opiate KappaAssay ConditionsBiochemistryMedicineRat Brain Membranes +8