Effect of Variations in the Amounts of P-Glycoprotein (ABCB1), BCRP (ABCG2) and CYP3A4 along the Human Small Intestine on PBPK Models for Predicting Intestinal First Pass

Arnaud Bruyère, Xavier Declèves, François Bouzom, +9

Molecular Pharmaceutics

Gastrointestinal PharmacologyGastroenterologyPathologyDigestive TractPbpk Models +14

Generation of proliferating human adult hepatocytes using optimized 3D culture conditions

Sophie Rose, Frédéric Ezan, Marie Cuvellier, +4

Scientific Reports

Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin

Lisa Chedik, Arnaud Bruyère, Marc Le Vée, +5

PLoS ONE

Transporter InhibitionPharmaceutical ScienceCellular PharmacologyPharmacotherapySystem Pharmacology +15

The JAK1/2 Inhibitor Ruxolitinib Reverses Interleukin-6-Mediated Suppression of Drug-Detoxifying Proteins in Cultured Human Hepatocytes

Marie Febvre-James, Arnaud Bruyère, Marc Le Vée, +1

Drug Metabolism and Disposition

In Silico Prediction for Intestinal Absorption and Brain Penetration of Chemical Pesticides in Humans

Lisa Chedik, Dominique Mias‐Lucquin, Arnaud Bruyère, +1

International Journal of Environmental Research and Public Health

DMSO-free highly differentiated HepaRG spheroids for chronic toxicity, liver functions and genotoxicity studies

Sophie Rose, Marie Cuvellier, Frédéric Ezan, +6

Archives of Toxicology

Heparg SpheroidsLiver FunctionsHepatologyMedicineLiver Physiology +8

Interactions of organophosphorus pesticides with solute carrier (SLC) drug transporters

Lisa Chedik, Arnaud Bruyère, Olivier Fardel

Xenobiotica

Development of an optimized procedure for the preparation of rat intestinal microsomes: comparison of hepatic and intestinal microsomal cytochrome P450 enzyme activities in two rat strains

Arnaud Bruyère, Xavier Declèves, François Bouzom, +4

Xenobiotica

Functional polarization of human hepatoma HepaRG cells in response to forskolin

Abdullah Mayati, A Moreau, Marc Le Vée, +5

Scientific Reports

ImmunologyFsk-treated Heparg CellsCellular PharmacologyCholangiopathiesCellular Physiology +20

Interactions of Endosulfan and Methoxychlor Involving CYP3A4 and CYP2B6 in Human HepaRG Cells

Camille C. Savary, Rozenn Jossé, Arnaud Bruyère, +3

Drug Metabolism and Disposition