The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

Corinne Venot

The EMBO Journal

Signal TransductionSignaling PathwayCell RegulationApoptosisGene Expression +7

Insulin-Like Growth Factor-1 Receptor Inhibition Induces a Resistance Mechanism via the Epidermal Growth Factor Receptor/HER3/AKT Signaling Pathway: Rational Basis for Cotargeting Insulin-Like Growth Factor-1 Receptor and Epidermal Growth Factor Receptor in Hepatocellular Carcinoma

Christèle Desbois‐Mouthon, Aurore Baron, Marie-José Blivet-Van Eggelpoël, +4

Clinical Cancer Research

Restoration of transcriptional activity of p53 mutants in human tumour cells by intracellular expression of anti-p53 single chain Fv fragments

Claude Caron de Fromentel, Nadège Gruel, Corinne Venot, +6

Oncogene

Tumor BiologyTumor SuppressorTranscriptional ActivitySystems BiologyMedicine +6

Definition of a p53 transactivation function-deficient mutant and characterization of two independent p53 transactivation subdomains

Corinne Venot, Michel Maratrat, Véronique Sierra, +2

Oncogene

Cell RegulationMolecular BiologyTumor SuppressorMedicineCell Biology +1

Grb2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor

Martine Pomérance, Marie-Christine Multon, Fabienne Parker, +4

Journal of Biological Chemistry

A humanised anti-IGF-1R monoclonal antibody (AVE1642) enhances Bortezomib-induced apoptosis in myeloma cells lacking CD45

Géraldine Descamps, Patricia Gomez‐Bougie, Corinne Venot, +3

British Journal of Cancer

CD45neg but Not CD45pos Human Myeloma Cells Are Sensitive to the Inhibition of IGF-1 Signaling by a Murine Anti-IGF-1R Monoclonal Antibody, mAVE1642

Géraldine Descamps, Soraya Wuillème‐Toumi, Valérie Trichet, +7

The Journal of Immunology

Design of Potent IGF1‐R Inhibitors Related to Bis‐azaindoles

Conception Nemecek, William A. Metz, Sylvie Wentzler, +10

Chemical Biology & Drug Design

Molecular PharmacologyMedicinal ChemistryPotent Bis-azaindole InhibitorsPharmaceutical ScienceMedicine +12

CTS1: a p53-derived chimeric tumor suppressor gene with enhanced in vitro apoptotic properties.

Emmanuel Conseiller, Laurent Debüssche, D Landais, +5

Journal of Clinical Investigation

Tumor BiologyVitro Apoptotic PropertiesWild-type P53OncologyClinical Potential +12

Anti-insulin-like growth factor 1 receptor antibody EM164 (murine AVE1642) exhibits anti-tumour activity alone and in combination with temozolomide against neuroblastoma

Birgit Geoerger, Jean‐François Brasme, Estelle Daudigeos‐Dubus, +5

European Journal of Cancer

Receptor Antibody Em164ImmunologyAnti-tumour ActivityImmunoeditingImmunotherapy +3