Modeling familial Alzheimer's disease with induced pluripotent stem cells

Takuya Yagi, Daisuke Ito, Yohei Okada, +6

Human Molecular Genetics

Cerebral OrganoidNeurochemical BiomarkersSynaptic SignalingPresenilin 1Fad-ipsc-derived Neuron +21

Characterization of Alternative Isoforms and Inclusion Body of the TAR DNA-binding Protein-43

Yoshinori Nishimoto, Daisuke Ito, Takuya Yagi, +3

Journal of Biological Chemistry

Establishment of Induced Pluripotent Stem Cells from Centenarians for Neurodegenerative Disease Research

Takuya Yagi, Arifumi Kosakai, Daisuke Ito, +9

PLoS ONE

Adult Stem CellCentenarian DonorsTherapeuticsStem Cell BiologyRegenerative Medicine +22

Mislocated FUS is sufficient for gain-of-toxic-function amyotrophic lateral sclerosis phenotypes in mice

Gen Shiihashi, Daisuke Ito, Takuya Yagi, +3

Brain

NeurogenomicsRna-binding ProteinsSynaptic SignalingSocial SciencesTranscriptional Regulation +20

Poly-glycine–alanine exacerbates C9orf72 repeat expansion-mediated DNA damage via sequestration of phosphorylated ATM and loss of nuclear hnRNPA3

Yoshihiro Nihei

Acta Neuropathologica

A Simple Technique for Reconstruction of the Umbilicus, Using Two Twisted Flaps

Takatoshi Yotsuyanagi, Yoshihiro Nihei, Yukimasa Sawada

Plastic & Reconstructive Surgery

Successful Umbilical ReconstructionSoft Tissue SurgeryAbdominal WallSimple TechniqueReconstructive Surgery +8

Clinical features and varieties of non-motor fluctuations in Parkinson's disease: A Japanese multicenter study

Morinobu Seki, Kazushi Takahashi, Daisuke Uematsu, +14

Parkinsonism & Related Disorders

Motor DysfunctionNeurophysiologyNeurological DisorderParkinson DiseaseClinical Features +8

Evidence of a link between ubiquilin 2 and optineurin in amyotrophic lateral sclerosis

Mayuko Osaka, Daisuke Ito, Takuya Yagi, +2

Human Molecular Genetics

Specific Endosomal VesiclesMolecular BiologyNeurochemical BiomarkersCytoskeletonSocial Sciences +17

Degeneration of mesencephalic dopaminergic neurons in klotho mouse related to vitamin D exposure

Arifumi Kosakai, Daisuke Ito, Yoshihiro Nihei, +4

Brain Research

Neurodegenerative DiseasesMedicinePhysiologyNeuropharmacologyNeuroprotection +7

N88S seipin mutant transgenic mice develop features of seipinopathy/BSCL2-related motor neuron disease via endoplasmic reticulum stress

Takuya Yagi, Daisuke Ito, Yoshihiro Nihei, +2

Human Molecular Genetics