Matthew Dowling

Discovery and Preclinical Characterization of 6-Chloro-5-[4-(1-hydroxycyclobutyl)phenyl]-1<i>H</i>-indole-3-carboxylic Acid (PF-06409577), a Direct Activator of Adenosine Monophosphate-activated Protein Kinase (AMPK), for the Potential Treatment of Diabetic Nephropathy

Kimberly O. Cameron, Daniel W. Kung, Amit S. Kalgutkar et al. · Journal of Medicinal Chemistry · 2016 · 117 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery and Optimization of Imidazopyridine-Based Inhibitors of Diacylglycerol Acyltransferase 2 (DGAT2)

Kentaro Futatsugi, Daniel W. Kung, Suvi T. M. Orr et al. · Journal of Medicinal Chemistry · 2015 · 83 citations

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of PF-06835919: A Potent Inhibitor of Ketohexokinase (KHK) for the Treatment of Metabolic Disorders Driven by the Overconsumption of Fructose

Kentaro Futatsugi, Aaron Smith, Meihua Tu et al. · Journal of Medicinal Chemistry · 2020 · 75 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17

Discovery of 2-(6-(5-Chloro-2-methoxyphenyl)-4-oxo-2-thioxo-3,4-dihydropyrimidin-1(2<i>H</i>)-yl)acetamide (PF-06282999): A Highly Selective Mechanism-Based Myeloperoxidase Inhibitor for the Treatment of Cardiovascular Diseases

Roger B. Ruggeri, Leonard Buckbinder, Scott W. Bagley et al. · Journal of Medicinal Chemistry · 2015 · 57 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +15

Discovery of Fragment-Derived Small Molecules for in Vivo Inhibition of Ketohexokinase (KHK)

Kim Huard, Kay Ahn, Paul A. Amor et al. · Journal of Medicinal Chemistry · 2017 · 49 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +17