Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, João A. Paulo, +22

Nature

Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways

Elizabeth T. Cirulli, Brittany N. Lasseigne, Slavé Petrovski, +67

Science

EngineeringExome SequencingGeneticsImmunologyDisease Gene Identification +16

Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

Rui Dong, Yasunori Saheki, Sharan Swarup, +3

Cell

Retromer FunctionChromatinProtein FunctionSignal TransductionVap-dependent Regulation +9

RAB7A phosphorylation by TBK1 promotes mitophagy via the PINK-PARKIN pathway

Jin‐Mi Heo, Alban Ordureau, Sharan Swarup, +4

Science Advances

Quantitative proteomics reveals the selectivity of ubiquitin-binding autophagy receptors in the turnover of damaged lysosomes by lysophagy

Vinay V. Eapen, Sharan Swarup, Melissa Hoyer, +2

eLife

MitophagyProteasomeMolecular BiologyQuantitative Organelle CaptureCell Autophagy +17

Deficiency of the frontotemporal dementia gene GRN results in gangliosidosis

Sebastian Boland, Sharan Swarup, Yohannes A. Ambaw, +16

Nature Communications

Homeodomain-interacting protein kinases (Hipks) promote Wnt/Wg signaling through stabilization of β-catenin/Arm and stimulation of target gene expression

Wendy Lee, Sharan Swarup, Joanna Chen, +2

Development

Molecular RegulationWnt/wg Signal TransductionTranscriptional RegulationHomeodomain-interacting Protein KinasesCell Regulation +14

Proteome census upon nutrient stress reveals Golgiphagy membrane receptors

Kelsey Hickey, Sharan Swarup, Ian R. Smith, +4

Nature

<i>Drosophila</i>homeodomain-interacting protein kinase inhibits the Skp1-Cul1-F-box E3 ligase complex to dually promote Wingless and Hedgehog signaling

Sharan Swarup, Esther M. Verheyen

Proceedings of the National Academy of Sciences

Environmental SignalingMolecular RegulationTranscriptional RegulationSignaling PathwayCell Regulation +14

Spatial snapshots of amyloid precursor protein intramembrane processing via early endosome proteomics

Hankum Park, Frances V Hundley, Qing Yu, +9

Nature Communications