Noah R. Aguayo

TGLI1 transcription factor mediates breast cancer brain metastasis via activating metastasis-initiating cancer stem cells and astrocytes in the tumor microenvironment

Sherona Sirkisoon, Richard L. Carpenter, Tadas Rimkus et al. · Oncogene · 2019 · 83 citations

Lineage Plasticity, Medicine, Stem Cells +11

Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Daniel Doheny, Sherona Sirkisoon, Richard L. Carpenter et al. · Oncogene · 2020 · 79 citations · Full text

Breast Oncology, Signaling Pathway, Medicine +12

Breast cancer extracellular vesicles-derived miR-1290 activates astrocytes in the brain metastatic microenvironment via the FOXA2→CNTF axis to promote progression of brain metastases

Sherona Sirkisoon, Grace L. Wong, Noah R. Aguayo et al. · Cancer Letters · 2022 · 57 citations · Full text

Foxa2→cntf Axis, Brain Metastases, Medicine +7

TrkA Interacts with and Phosphorylates STAT3 to Enhance Gene Transcription and Promote Breast Cancer Stem Cells in Triple-Negative and HER2-Enriched Breast Cancers

Angelina T. Regua, Noah R. Aguayo, Sara Abu Jalboush et al. · Cancers · 2021 · 19 citations · Full text

An FDA-Approved Antifungal, Ketoconazole, and Its Novel Derivative Suppress tGLI1-Mediated Breast Cancer Brain Metastasis by Inhibiting the DNA-Binding Activity of Brain Metastasis-Promoting Transcription Factor tGLI1

Daniel Doheny, Sara G. Manore, Sherona Sirkisoon et al. · Cancers · 2022 · 15 citations · Full text