Nhin Lu

A Clinically Relevant Androgen Receptor Mutation Confers Resistance to Second-Generation Antiandrogens Enzalutamide and ARN-509

James D. Joseph, Nhin Lu, Jing Qian et al. · Cancer Discovery · 2013 · 570 citations · Full text

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

Andiliy Lai, Mehmet Kahraman, Steven P. Govek et al. · Journal of Medicinal Chemistry · 2015 · 244 citations · Full text

Breast Oncology, Chemoprevention Strategy, Pharmacotherapy +16

The selective estrogen receptor downregulator GDC-0810 is efficacious in diverse models of ER+ breast cancer

James D. Joseph, Beatrice Darimont, Wei Zhou et al. · eLife · 2016 · 117 citations · Full text

Diverse Models, Breast Oncology, Erα Signaling +16

Optimization of an indazole series of selective estrogen receptor degraders: Tumor regression in a tamoxifen-resistant breast cancer xenograft

Steven P. Govek, Johnny Nagasawa, Karensa Douglas et al. · Bioorganic & Medicinal Chemistry Letters · 2015 · 46 citations

Tumor Regression, Breast Oncology, Oncology +10

Identification of an Orally Bioavailable Chromene-Based Selective Estrogen Receptor Degrader (SERD) That Demonstrates Robust Activity in a Model of Tamoxifen-Resistant Breast Cancer

Johnny Nagasawa, Steven P. Govek, Mehmet Kahraman et al. · Journal of Medicinal Chemistry · 2018 · 37 citations · Full text

Breast Oncology, Chemoprevention Strategy, Pharmacotherapy +18