A Comprehensive Panel of Three-Dimensional Models for Studies of Prostate Cancer Growth, Invasion and Drug Responses

Ville Härmä, Johannes Virtanen, Rami Mäkelä, +7

PLoS ONE

Three-dimensional ModelsComprehensive PanelCell CultureTumor BiologyProstate Cancer Growth +18

Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion

Mari Björkman, Päivi Östling, Ville Härmä, +11

Oncogene

Histone ModificationsChromatinChromatin RemodelingEpigenetic ChangeEpigenomics +8

Quantification of Dynamic Morphological Drug Responses in 3D Organotypic Cell Cultures by Automated Image Analysis

Ville Härmä, Hannu-Pekka Schukov, Antti P. Happonen, +6

PLoS ONE

EngineeringMicroscopyCell CultureBiomedical EngineeringCellular Physiology +20

Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens

Bastien Laperrousaz, Stephanie Porte, Sophie Gerbaud, +6

Nucleic Acids Research

Tissue EngineeringEngineeringMatrigel MicrobeadsTransgene ExpressionSingle-cell Encapsulation +22

Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models

Ville Härmä, Matias Knuuttila, Johannes Virtanen, +10

Oncogene

Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling

James R. W. Conway, Aleksi Isomursu, Gautier Follain, +6

Proceedings of the National Academy of Sciences

EngineeringCell AdhesionAdhesion SignalingCytoskeletonStiffness-insensitive Cell Spreading +20

Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention

Malin Åkerfelt, Neslihan Bayramoğlu, Sean M. Robinson, +10

Oncotarget

Optimization of Invasion-Specific Effects of Betulin Derivatives on Prostate Cancer Cells through Lead Development

Ville Härmä, Raisa Haavikko, Johannes Virtanen, +9

PLoS ONE

Betulin DerivativesUrologyOncologyChemoprevention StrategyGenitourinary Cancer +13

Image-based ex vivo drug screen to assess targeted therapies in recurrent thymoma

Antti Arjonen, Rami Mäkelä, Ville Härmä, +4

Lung Cancer

Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma

Rami Mäkelä, Antti Arjonen, Aldwin Suryo Rahmanto, +7

Neoplasia