Fusion between a novel Krüppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia.

Z Chen, Nigel J. Brand, A. Chen, +5

The EMBO Journal

Hematological MalignancyGeneticsHematologyPathologyVariant T +6

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.

S J Chen, Arthur Zelent, Jianhua Tong, +6

Journal of Clinical Investigation

PLZF-RAR alpha fusion proteins generated from the variant t(11;17)(q23;q21) translocation in acute promyelocytic leukemia inhibit ligand-dependent transactivation of wild-type retinoic acid receptors.

Z Chen, Fabien Guidez, Philippe Rousselot, +7

Proceedings of the National Academy of Sciences

Hematological MalignancySignal TransductionProtein ExpressionNatural SciencesMixed-phenotype Acute Leukemia +11

Clinical and cytogenetic features of 508 Chinese patients with myelodysplastic syndrome and comparison with those in Western countries

B Chen, W-L Zhao, Jie Jin, +17

Leukemia

Hematological MalignancyMyelodysplastic SyndromeBone Marrow FailureWestern CountriesMixed-phenotype Acute Leukemia +6

Rapid induction of cAMP/PKA pathway during retinoic acid-induced acute promyelocytic leukemia cell differentiation

Qian Zhao, Jianguo Tao, Qian Zhu, +10

Leukemia

Signal TransductionDevelopmental BiologyRapid InductionSignaling PathwayMixed-phenotype Acute Leukemia +6

Homoharringtonine in combination with cytarabine and aclarubicin resulted in high complete remission rate after the first induction therapy in patients with de novo acute myeloid leukemia

Ji-Qiang Jin, D-Z Jiang, H-T Meng, +7

Leukemia

Hematological MalignancyMedicineAcute Myeloid LeukemiaMixed-phenotype Acute LeukemiaHematology +6

Predictive and prognostic value of admission neutrophil-to-lymphocyte ratio in patients with CHD

Chao Yu, M. Chen, Z Chen, +1

Herz

Lymphoid NeoplasiaAutoimmune DiseaseDisease ProgressionGranulocyteMalignant Blood Disorder +8

A new fusion gene NUP98-IQCG identified in an acute T-lymphoid/myeloid leukemia with a t(3;11)(q29q13;p15)del(3)(q29) translocation

Qin Pan, Y-J Zhu, B-W Gu, +9

Oncogene

Acute T-lymphoid/myeloid LeukemiaChromatinHematological MalignancyMixed-phenotype Acute LeukemiaGenetics +7

Problems existing in differentiation therapy of acute promyelocytic leukemia (APL) with all-trans retinoic acid (ATRA).

Wang Zy, Z Chen, Wei‐Cheng Huang, +7

PubMed

Hematological MalignancyPml GeneOncologyDifferentiation TherapyRetinoic Acid Syndrome +12

Molecular response in acute promyelocytic leukemia: a direct comparison of regular and real-time RT-PCR

Y‐F Liu, Y‐M Zhu, S-H Shen, +5

Leukemia

Hematological MalignancyMedicineMixed-phenotype Acute LeukemiaMalignant Blood DisorderImmunology +11