Bortezomib overcomes cell adhesion-mediated drug resistance through downregulation of VLA-4 expression in multiple myeloma

Kaoru Hatano, Jiro Kikuchi, Masaaki Takatoku, +14

Oncogene

Hematological MalignancyAdhesion-mediated Drug ResistanceImmunologyMultiple MyelomaAnti-cancer Agent +5

Cloning and characterization of novel snake venom proteins that block smooth muscle contraction

Yasuo Yamazaki, Hisashi Koike, Yusuke Sugiyama, +5

European Journal of Biochemistry

Histone deacetylases are critical targets of bortezomib-induced cytotoxicity in multiple myeloma

Jiro Kikuchi, Taeko Wada, Rumi Shimizu, +8

Blood

Ablation of Neutral Cholesterol Ester Hydrolase 1 Accelerates Atherosclerosis

Motohiro Sekiya, Jun-ichi Osuga, Shuichi Nagashima, +18

Cell Metabolism

BiochemistryCardiovascular DiseaseVascular BiologyLipoprotein MetabolismAccelerates Atherosclerosis +2

HDAC inhibitors augment cytotoxic activity of rituximab by upregulating CD20 expression on lymphoma cells

R Shimizu, Jiro Kikuchi, Taeko Wada, +3

Leukemia

Lymphoid NeoplasiaMedicineLymphoma CellsMalignant Blood DisorderImmunology +7

Phosphorylation-mediated EZH2 inactivation promotes drug resistance in multiple myeloma

Jiro Kikuchi, Daisuke Koyama, Taeko Wada, +4

Journal of Clinical Investigation

Histone ModificationsCancer BiologyEpigeneticsTumor BiologyDrug Resistance +15

Methylation Silencing of the <i>Apaf-1</i> Gene in Acute Leukemia

Yutaka Furukawa, Krittaya Sutheesophon, Taeko Wada, +4

Molecular Cancer Research

Histone deacetylase 1 enhances microRNA processing via deacetylation of DGCR8

Taeko Wada, Jiro Kikuchi, Yusuke Furukawa

EMBO Reports

Histone ModificationsChromatinChromatin StructureChromatin RemodelingNatural Sciences +11

Expression Levels of Histone Deacetylases Determine the Cell Fate of Hematopoietic Progenitors

Taeko Wada, Jiro Kikuchi, Noriko Nishimura, +3

Journal of Biological Chemistry

Histone ModificationsHistone DeacetylasesMixed-phenotype Acute LeukemiaGeneticsEpigenetic Change +19

Splicing- and demethylase-independent functions of LSD1 in zebrafish primitive hematopoiesis

Junya Tamaoki, Miki Takeuchi, Ryo Abe, +6

Scientific Reports